Autophagy is Impaired in the Tibialis Anterior of Dystrophin Null Mice
Conclusions
This study demonstrates that autophagy was not induced after fasting in the tibialis anterior muscle of dystrophin null mice. Autophagy was potently induced in the diaphragm muscle of mdx as well as wt mice. The difference between the two types of skeletal muscle underlines the fact that a specific treatment to improve muscle condition could have a different effect in different types of muscle.
Corrisponding authors
Annemieke Aartsma-Rus
Human Genetics Department
Leiden University Medical Center
A.M.Aartsma-Rus@lumc.nl
Paolo Bonaldo
Department of Molecular Medicine
University of Padova
bonaldo@bio.unipd.it
Keywords
Duchenne Muscular Dystrophy; Autophagy; Macroautophagy; mdx mouse.
Competing Interests
The authors have declared that no competing interests exist.
Acknowledgements
Peter ‘t Hoen is acknowledged for critical suggestions and discussion over the results. Willeke van Roon-Mom is acknowledged for revising the English throughout the text.
* Pietro Spitali and Paolo Grumati contributed equally to this work
Source: PLOS Currents Muscular Dystrophy - Category: Neurology Authors: pietrospitali Source Type: research
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