Atypical language lateralization: an fMRI study in patients with cerebral lesions.

Atypical language lateralization: an fMRI study in patients with cerebral lesions. Funct Neurol. 2013 Jan-Mar;28(1):55-61 Authors: Fakhri M, Oghabian MA, Vedaei F, Zandieh A, Masoom N, Sharifi G, Ghodsi M, Firouznia K Abstract Differences in the lateralization of language processes between healthy subjects and patients with neurological complaints other than epilepsy have been less documented than those between healthy subjects and epilepsy patients. Moreover, the contribution of factors such as the location and type of lesion in determining interhemispheric shift of language function is poorly understood. Sixty-seven patients who underwent presurgical evaluations at the Medical Imaging Center of the Imam Khomeini University Hospital, Tehran, and the same number of healthy controls, were recruited. The laterality index (LI) of language activation, calculated from two separate functional magnetic resonance imaging tasks, was compared between the patients and the age-/gender-/handedness-matched controls. Chi square testing showed that the percentages of subjects with "typical" and "atypical" language dominance in the patient group were significantly different from the percentages recorded in the matched healthy controls for both tasks (p<0.005). Lesion type, lesion location, lesion hemisphere, presenting symptom and patient gender had no statistically significant effect on the hemispheric LI (p>0.05). In a logistic regression mod...
Source: Functional Neurology - Category: Neurology Tags: Funct Neurol Source Type: research