Altered information processing in children with focal epilepsies with and without intellectual disability.

Altered information processing in children with focal epilepsies with and without intellectual disability. Funct Neurol. 2014 Jul 4;Early view:1-11 Authors: Japaridze N, Schark M, von-Ondarza G, Boor R, Muhle H, Gerber WD, Stephani U, Siniatchkin M Abstract The aim of this exploratory study was to investigate the relationship between focal interictal epileptiform discharges (IEDs), intellectual disability and cortical information processing in children with partial epilepsy. Two groups of patients - Group 1 (n = 9 patients) with focal IEDs and normal IQ and Group 2 (n = 10 patients) with focal IEDs and intellectual disability - were compared with 14 healthy control participants. A computerized choice reaction time task (go/no-go paradigm) was performed and event-related potentials (ERPs) were recorded. When an IED occurred during the period between the presentation of the stimulus and the response, the response was defined as a response with IED. Omission errors, commission errors and reaction time were evaluated in temporal relationship to IEDs. The Group 1 patients did not differ from the healthy children in neurophysiological functions and ERP amplitudes. The Group 2 children showed inferior Altered information processing in children with focal epilepsies with and without intellectual disability performances in verbal learning and memory, cognitive flexibility and selective attention, and were characterized by low ERP amplitudes c...
Source: Functional Neurology - Category: Neurology Tags: Funct Neurol Source Type: research