Aberrant expression of alternative splicing variants in multiple sclerosis – A systematic review

ConclusionsAn altered RNA processing of genes mediating immune signaling pathways has been repeatedly implicated in MS. The analysis of individual exon-level expression patterns is stimulated by the advancement of transcriptome profiling technologies. In particular, the examination of genes encoded in MS-associated genetic regions may provide important insights into the pathogenesis of the disease and help to identify new biomarkers.
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research