Polymorphisms of the BARX1 and ADAMTS17 locus genes in individuals with gastroesophageal reflux disease.

Conclusion: : This is a study investigating the potential correlation between 2 BARX1 and ADAMTS17 polymorphisms and the development of GERD, showing a considerable association between both polymorphisms and the disease. This finding suggests that esophageal differentiation or altered regulation on microfibrils in the cell environment could be implicated as possible mechanisms in the pathogenesis of GERD. PMID: 31048564 [PubMed - as supplied by publisher]
Source: Journal of Neurogastroenterology and Motility - Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

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The objective of this study was to review the current status of drug-induced hypomagnesemia and its adverse effects on cardiovascular disease (CVD) and hypertension. Since magnesium is a potent vasodilator, which modulates vasomotor tone, peripheral blood flow and hypertension, its deficiency could have significant cardiovascular and blood pressure (BP) effects.Areas covered: Studies have shown that several factors can contribute to magnesium deficiency including age, diet, disease, and certain drugs such as diuretics and proton pump inhibitors (PPIs). For an updated perspective of drug-induced hypomagnesemia, a Medline se...
Source: Expert Opinion on Drug Safety - Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research
Authors: Chen C, Gong X, Yang X, Shang X, Du Q, Liao Q, Xie R, Chen Y, Xu J Abstract Estrogen is an important sex steroid hormone which serves an important role in the regulation of a number of biological functions, including regulating bone density, brain function, cholesterol mobilization, electrolyte balance, skin physiology, the cardiovascular system, the central nervous system and female reproductive organs. Estrogen exhibits various functions through binding to its specific receptors, estrogen receptor α, estrogen receptor β and G protein-coupled estrogen receptor 1. In recent years, researchers ha...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
ConclusionsRYGB is an effective therapy for patients with BE and reflux after SG. Its outcomes in the current study were BE remission in the majority of cases as well as a decrease in reflux activity. Further studies with larger cohorts are necessary to confirm these findings.
Source: Obesity Surgery - Category: Surgery Source Type: research
AbstractThe Indian Society of Gastroenterology developed this evidence-based practice guideline for management of gastroesophageal reflux disease (GERD) in adults. A modified Delphi process was used to develop this consensus containing 58 statements, which were generated by electronic voting iteration as well as face-to-face meeting and review of the supporting literature primarily from India. These statements include 10 on epidemiology, 8 on clinical presentation, 10 on investigations, 23 on treatment (including medical, endoscopic, and surgical modalities), and 7 on complications of GERD. When the proportion of those who...
Source: Indian Journal of Gastroenterology - Category: Gastroenterology Source Type: research
We describe this unusual case which was treated effectively with ARMS. PMID: 31791169 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
(Natural News) According to the website Healthline.com, upwards of 30 percent of all Americans suffer from Gastroesophageal Reflux Disease (GERD), a chronic condition which causes heartburn or indigestion several times a week. In addition, millions more people struggle with heartburn on a regular basis, even if they haven’t been officially diagnosed with GERD. Doctors are...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
ConclusionOAGB is more effective for %EWL and dyslipidemia remission than SG. In addition, OAGB may lower the risk of postoperative leak, gastroesophageal reflux disease, revision, and mortality. Further comparisons of the clinical outcomes of OAGB versus SG for morbid obesity would benefit from more high-quality controlled studies.
Source: Obesity Surgery - Category: Surgery Source Type: research
Conditions:   Patient Satisfaction;   Relapse;   Dysphagia;   Bloating Intervention:   Other: 10 years follow up Sponsor:   Karolinska Institutet Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
AbstractBackgroundThe purpose of this study was to determine whether magnetic sphincter augmentation (MSA) could effectively treat patients with gastroesophageal reflux disease (GERD) who suffer primarily fromatypical symptoms due to laryngopharyngeal reflux (LPR). MSA has been shown to treattypical symptoms of GERD with good success, but its effect onatypical symptoms is unknown.MethodsA retrospective review of a prospectively maintained institutional review board-approved database was conducted for all patients who underwent MSA between January 2015 and December 2018. All patients had objective confirmation of GERD from ...
Source: Surgical Endoscopy - Category: Surgery Source Type: research
ConclusionsPersistent tHH seems to be a pathological finding associated with pathological reflux.
Source: Journal of Gastrointestinal Surgery - Category: Surgery Source Type: research
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