Recent advances in antibacterial applications of metal nanoparticles (MNPs) and metal nanocomposites (MNCs) against multidrug-resistant (MDR) bacteria.

Recent advances in antibacterial applications of metal nanoparticles (MNPs) and metal nanocomposites (MNCs) against multidrug-resistant (MDR) bacteria. Expert Rev Anti Infect Ther. 2019 May 02;: Authors: Alavi M, Rai M Abstract INTRODUCTION: In recent years, multidrug-resistance in bacteria has drastically increased and has posed a great threat to the human health. This problem has generated an urgent need to search alternatives for the treatment of MDR bacteria. It has been proved that metal nanoparticles (MNPs) and nanocomposites (MNCs) possess remarkable antimicrobial potential, and hence can be used in alternative therapy. Areas covered: This review is aimed to discuss recent reports on antibacterial activities of MNPs and MNCs against MDR bacteria. Expert opinion: Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Acinetobacter baumannii, Klebsiella pneumoniae, Serratia marcescens, Streptococcus pneumoniae, and Staphylococcus epidermidis are important pathogenic bacteria which have shown multidrug resistance (MDR) against a wide range of conventional antibiotics. In this context, effects of metal nanopartilcles (MNPs) and metal nanocomposites (MNCs) on these pathogens have demonstrated considerable efficacy. Several mechanisms concerning activity of MNPs and MNCs against pathogenic bacteria which are mainly dependent on type of their precursors and treated bacterium have been investigated. In addition, many studies...
Source: Expert Review of Anti-Infective Therapy - Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research