Molecules, Vol. 24, Pages 1739: Small Molecule Inhibitors of KDM5 Histone Demethylases Increase the Radiosensitivity of Breast Cancer Cells Overexpressing JARID1B

Conclusions: These findings confirm the involvement of H3K4 specific demethylases in the response to DNA damage, show a requirement of the catalytic function and suggest new strategies for the therapeutic use of their inhibitors.

Source: Molecules - May 3, 2019 Category: Chemistry Authors: Simone Pippa Cecilia Mannironi Valerio Licursi Luca Bombardi Gianni Colotti Enrico Cundari Adriano Mollica Antonio Coluccia Valentina Naccarato Giuseppe La Regina Romano Silvestri Rodolfo Negri Tags: Article Source Type: research