Five new diterpenoids from the barks of Cinnamomum cassia (L.) J. Presl

Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Van Cong Pham, Thi Thuy An Nguyen, Thi Oanh Vu, Thao Quyen Cao, Byung Sun Min, Jeong Ah KimAbstractHere, we report the isolation of five new diterpenoids including four lactone-type diterpenes (3, 5-7) and a hemiketal-type diterpene (12) in addition to 10 known compounds from the bark of Cinnamomum cassia (L.) J. Presl. Molecular structures were elucidated by various spectroscopic methods including 1- and 2-dimensional NMR, high-resolution MS, and circular dichroism. No cytotoxic activity was observed for any of the isolated compounds (1-15) as examined in vitro in three cancer cell lines (HeLa, HL-60, and MCF-7) using the MTT assay.Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research