Risk factors for local recurrence of hepatocellular carcinoma after transcatheter arterial chemoembolization with drug-eluting beads (DEB-TACE)

AbstractPurposeTo identify the risk factors for local recurrence in hepatocellular carcinoma (HCC) patients treated with transcatheter arterial chemoembolization (TACE) with drug-eluting beads (DEB-TACE).Materials and methodsIn this retrospective study, 35 patients (27 males, 8 females; median age 73  years) with 116 tumors (median size 14 mm) treated with DEB-TACE from May 2014 to September 2018 were evaluated. Age, sex, etiology, Child–Pugh class, alpha-fetoprotein, des-gamma-carboxyprothrombin, previous conventional TACE, tumor location, tumor size, tumor number, contact with the liver su rface, level of embolization, corona enhancement on CT during hepatic arteriography, vascular lakes, additional embolization with gelatin sponge particles, and supplying vessels on digital subtraction angiography (DSA) after embolization were analyzed.ResultsUnivariate analysis showed that advanced age, female, large tumor, contact with the liver surface, and residual supplying vessels were significant risk factors for local recurrence (p  =  0.012, 0.0013, 0.0023, 0.025, and 
Source: Japanese Journal of Radiology - Category: Radiology Source Type: research

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PMID: 31189328 [PubMed - as supplied by publisher]
Source: Acta Radiologica - Category: Radiology Authors: Tags: Acta Radiol Source Type: research
Resumo A quimioemboliza ção arterial transcateter consiste em promover isquemia e ação citotóxica por meio da injeção de microesferas contendo quimioterápicos aplicada seletivamente nos vasos que nutrem o tumor. Paciente do sexo feminino, com 87 anos, em tratamento paliativo para carcinoma hepatocelular com indicaç ão de quimioembolização, foi submetida a angiografia pré-procedimento, a qual identificou oclusão do tronco celíaco. A opção foi a cateterismo seletiva da artéria hepática pr&oacut...
Source: Jornal Vascular Brasileiro - Category: Surgery Source Type: research
1315Introduction: Since the introduction of transarterial radioembolization (TARE) for the treatment of liver malignancies a key pre therapy step has been to assess for potential lung shunting with a hepatic arterial injection of Tc-MAA and a quantitative image assessment of the radiopharmaceutical distribution. However this causes the need for additional costs and morbidity as well as a treatment delay. Literature and our experience has suggested that a critical evaluation of the cross sectional imaging prior to therapy may help predict when significant shunting to the lungs may be present. We wanted to evaluate which ima...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Image-Guided Therapy Posters Source Type: research
American Journal of Roentgenology, Ahead of Print.
Source: American Journal of Roentgenology - Category: Radiology Authors: Source Type: research
ConclusionsWe developed a method for quantitating tumor blush using routine angiographic images. The VEVs calculated using these images may allow for the prediction of tumor response to therapy. This pilot study suggests that there is a correlation between tumor blush intensity and tumor response.
Source: Abdominal Imaging - Category: Radiology Source Type: research
Conclusion: For HCC with tumor thrombus in the IVC and RA, TACE could safely improve the prognosis of these patients. Searching for multiple feeding arteries are essential for ensuring efficacy. In addition, careful examination and appropriate embolization technique are essential for safety and efficacy. Lipiodol was a safe and ideal agent for the embolization in RATT.
Source: Journal of Cancer Research and Therapeutics - Category: Cancer & Oncology Authors: Source Type: research
ConclusionThis technique can be useful in decreasing HABP and collateral blood flow from the adjacent hepatic segment.
Source: Japanese Journal of Radiology - Category: Radiology Source Type: research
Radioembolization with Yttrium-90 (Y90) has been proven safe and effective for the treatment of primary and secondary hepatic malignancies. Standard protocols have necessitated planning angiography with Technetium-99m macroaggregated albumin (Tc99m MAA) administration/scan typically 1-2 weeks prior to the radioembolization therapy. The intent of this practice is to ensure appropriate patient selection and treatment candidacy while also confirming best dosimetry approaches. At our center, we started performing “same-day Y90” in 2008; in a subset of international patients with travel hardship, we performed the pl...
Source: Techniques in Vascular and Interventional Radiology - Category: Radiology Authors: Source Type: research
Publication date: March 2019Source: Journal of Vascular and Interventional Radiology, Volume 30, Issue 3Author(s): Kyung Ah Kim, Sun Young Choi, Min Uk Kim, Seung Yon Baek, Sang Hui Park, Kwon Yoo, Tae Hun Kim, Hwi Young KimAbstractPurposeTo evaluate efficacy of cone-beam CT–based liver perfusion mapping obtained immediately following conventional transarterial chemoembolization of hepatocellular carcinoma (HCC) for assessing tumor vascularity, technical success of chemoembolization, and treatment response.Materials and MethodsFrom July 2015 to June 2016, 35 patients with 57 HCCs who underwent cone-beam CT with post-...
Source: Journal of Vascular and Interventional Radiology - Category: Radiology Source Type: research
ConclusionsA same-day 90Y radioembolization protocol with resin microspheres is feasible in select patients, which can expedite cancer therapy.
Source: Journal of Vascular and Interventional Radiology - Category: Radiology Source Type: research
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