Vitamin D 3 from Ultraviolet-B Exposure or Oral Intake in Relation to Cancer Incidence and Mortality

AbstractPurpose of ReviewThis review summarizes the understanding of vitamin D3’s role in reducing risk of cancer incidence and mortality.Recent FindingsRecent randomized clinical trials and observational studies of participants who took part in vitamin D3 supplementation studies provide increasing evidence that concentrations of serum 25-hydroxyvitamin D3 [25(OH)D3] up to ~  60 ng/ml are inversely correlated with all cancer and some specific cancers’ incidence and death, with a stronger effect on survival and death than on incidence. Mechanisms linking vitamin D3 to effects on cellular proliferation, anti-angiogenesis, and anti-metastasis continue to be found.SummaryVitamin D3 reduces cancer risk causally. Maintaining 25(OH)D3 in the range of 40 –60 ng/ml reduces the risk of many cancers. Raising 25(OH)D3 concentrations after diagnosis to that range increases survival rates and could significantly reduce the global burden of cancer incidence and death.
Source: Current Nutrition Reports - Category: Nutrition Source Type: research