Diffuse idiopathic skeletal hyperostosis in smokers is associated with Restrictive Spirometry Pattern: an analysis in the COPDGene cohort.

This study investigated whether DISH is associated with restrictive spirometry pattern (RSP) in former and current smokers. METHODS: 1,784 participants with complete post-bronchodilator spirometry who did not meet spirometric criteria for COPD at time of enrollment in the COPDGene study were included in this study. Subjects were classified as RSP if they had Forced Expiratory volume in one second \(FEV1) to Forced Vital Capacity (FVC) ratio> 0.7 with an FVC
Source: J Rheumatol - Category: Rheumatology Authors: Tags: J Rheumatol Source Type: research

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Publication date: Available online 17 August 2019Source: Respiratory Physiology &NeurobiologyAuthor(s): Miao Zhou, Li Jiao, Yuanyuan LiuAbstractImbalance between inflammatory Th17 cells and immunosuppressive regulatory T cells (Treg) contributes to the progression of chronic obstructive pulmonary disease (COPD). We aims to investigate roles and mechanisms of secreted frizzled-related protein 2 (sFRP2) in airway inflammation and Th17/Treg differentiation in COPD. sFRP2 was significantly upregulated in the serum of patients with COPD and in human bronchial epithelial (HBE) cells that were exposed to cigarette smoke extra...
Source: Respiratory Physiology and Neurobiology - Category: Respiratory Medicine Source Type: research
Photo credit Todd Cravens Dear Carol: My mom is 85 and has lived with COPD, diabetes, and heart disease for the last ten years, but she’s been a fighter. She’s always said that she didn’t want extreme measures to keep her alive when her time to go was obvious, and I agreed, but now that the end seems close I think that she should fight longer. She qualifies for hospice, but hospice means that she must stop the medications that are keeping her alive. Mom says that she’s fought long enough and she’s done with that. She just wants comfort for as long as she has left. It’s true that I h...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
People with HIV are greater risk of developing illnesses that are normally associated with age, such as increased incidence of heart disease, chronic obstructive pulmonary disease and bone fractures.
Source: Nursing Times - Category: Nursing Source Type: news
An important goal of chronic obstructive pulmonary disease (COPD) treatment is to reduce the frequency of exacerbations. Some observations suggest a decline in exacerbation rates in clinical trials over time. ...
Source: Respiratory Research - Category: Respiratory Medicine Authors: Tags: Research Source Type: research
Abstract Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease with multiple molecular mechanisms. To investigate and contrast the molecular processes differing between bronchiolitis and emphysema phenotypes of COPD, we downloaded the GSE69818 microarray data set from the Gene Expression Omnibus (GEO), which based on lung tissues from 38 patients with emphysema and 32 patients with bronchiolitis. Then, weighted gene coexpression network analysis (WGCNA) and differential coexpression (DiffCoEx) analysis were performed, followed by gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes enri...
Source: J Cell Mol Med - Category: Molecular Biology Authors: Tags: J Cell Mol Med Source Type: research
To assess the budget impact of restricting inappropriate inhaled corticosteroids (ICS) use according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD)-guidelines indication for ICS use in the chronic obstructive pulmonary disease (COPD)-population, taking The Netherlands as a reference case.
Source: Value in Health - Category: International Medicine & Public Health Authors: Source Type: research
Conclusions: The ACO cohort with statin use exhibited the lower risk of hepatic, renal, and heart failure than any other cohort, regardless of age, sex, comorbidities, or ICS or OS use. Regarding the combined use of statins and ICS, the risks of hepatic failure were lower. For the combined use of statins and OS, the hepatic, renal and heart failure were less frequent.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
The objective of this study was to compare the 30-day outcomes for these two treatment groups for multilevel cervical pathology. Methods. Patients who underwent cervical laminoplasty or posterior laminectomy and fusion were identified in National Surgical Quality Improvement Program (NSQIP) based on Current Procedural Terminology (CPT) code: laminoplasty 63,050 and 63,051, posterior cervical laminectomy 63,015 and 63,045, and instrumentation 22,842. Propensity-adjusted multivariate regressions assessed differences in postoperative length of stay, adverse events, discharge disposition, and readmission. Results. Three ...
Source: Spine - Category: Orthopaedics Tags: CERVICAL SPINE Source Type: research
This study demonstrated that US adults with COPD have a much higher prevalence of arthritis than those without, even when accounting for sociodemographic factors and other variables.Preventing Chronic Disease
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Public Health & Prevention Journal Article Source Type: news
Source: Clinical Nutrition - Category: Nutrition Authors: Tags: Geriatrics II Source Type: research
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