Things are changing for head and neck squamous cell carcinomas

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Source: Current Opinion in Oncology - Category: Cancer & Oncology Tags: HEAD AND NECK: Edited by Joël Guigay Source Type: research

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CONCLUSIONS: In our population-based cohort of HIV-infected subjects with long-term follow-up, the risk of progression from anal intraepithelial neoplasia III to anal squamous cell carcinoma was higher than reported in other studies and was not associated with the receipt of anal intraepithelial neoplasia III treatment. See Video Abstract at
Source: Diseases of the Colon and Rectum - Category: Gastroenterology Tags: Original Contributions: Colorectal Cancer Source Type: research
by Christian Gluck, Alexandra Glathar, Maria Tsompana, Norma Nowak, Lee Ann Garrett-Sinha, Michael J. Buck, Satrajit Sinha Head and Neck Squamous Cell Carcinoma (HNSCC) is a heterogeneous disease of significant mortality and with limited treatment options. Recent genomic analysis of HNSCC tumors has identified several distinct molecular classes, of which the mesenchymal subtype is associated with Epithelial to Mesench ymal Transition (EMT) and shown to correlate with poor survival and drug resistance. Here, we utilize an integrated approach to characterize the molecular function of ETS1, an oncogenic transcription factor ...
Source: PLoS Genetics - Category: Genetics & Stem Cells Authors: Source Type: research
ConclusionThis study identified effective and reliable molecular biomarkers for diagnosis and prognosis by integrated bioinformatics analysis, suggesting novel and essential therapeutic targets for HNSCC.
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: ORIGINAL ARTICLE Source Type: research
AbstractHead and neck cancers, including those of the lip and oral cavity, nasal cavity, paranasal sinuses, oropharynx, larynx and nasopharynx represent nearly 700,000 new cases and 380,000 deaths worldwide per annum, and account for over 10,000 annual deaths in the United States alone. Improvement in outcomes are needed for patients with recurrent and or metastatic squamous cell carcinoma of the head and neck (HNSCC). In 2016, the US Food and Drug Administration (FDA) granted the first immunotherapeutic approvals – the anti-PD-1 immune checkpoint inhibitors nivolumab and pembrolizumab – for the treatment of pa...
Source: Journal for Immunotherapy of Cancer - Category: Cancer & Oncology Source Type: research
Publication date: Available online 12 July 2019Source: European Journal of Surgical OncologyAuthor(s): Anna Beltz, Dorothée Gösswein, Stefanie Zimmer, Ivonne Limburg, Desirée Wünsch, Alena Gribko, Maximilian Deichelbohrer, Jan Hagemann, Roland H. Stauber, Julian Künzel
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
Conclusions: Our results demonstrate that miR-216a-5p might serve as a tumor suppressor in ESCC cells through negatively regulating TCTN1 expression, indicating the possibility that miR-216a-5p and TCTN1 might be attractive targets for ESCC therapeutic intervention. PMID: 31297133 [PubMed - in process]
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Cell Mol Biol Lett Source Type: research
Publication date: Available online 12 July 2019Source: Pathology - Research and PracticeAuthor(s): Mingzhu Zong, Yan Liu, Kai Zhang, Yi J, Longbang ChenAbstractIncreasing evidence indicates that microRNAs may play important roles in tumor development and may take part in different processes in different cancers. miR-429 is known as a cancer suppressor or oncogene that is dysregulated in different malignancies, including esophageal squamous cell carcinoma (ESCC). However, the effect of miR-429 in ESCC has not been fully explored. The purpose of this study was to investigate the functions of miR-429 in ESCC. qRT-PCR assays w...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
This article presents the case of a patient with diagnosed squamous cell carcinoma arising from chronic sacrococcygeal pilonidal disease. In this article was presented the clinical features, pathogenesis, treatment options and prognosis of this rare disease. KEY WORDS: Pilonidal disease, Skin carcinoma, Squamous cell carcinoma, Surgery. PMID: 31293248 [PubMed - in process]
Source: Annali Italiani di Chirurgia - Category: Surgery Tags: Ann Ital Chir Source Type: research
AbstractAccording to diagnostic criteria, skin tumors can be divided into three categories: benign, low degree and high degree malignancy. For high degree malignant skin tumors, if not detected in time, they can do serious harm to patients ’ health. However, in clinical practice, identifying malignant degree requires biopsy and pathological examination which is time costly. Furthermore, in many areas, due to the severe shortage of dermatologists, it’s inconvenient for patients to go to hospital for examination. Therefore, an easy to access screening method of malignant skin tumors is needed urgently. Firstly, w...
Source: Journal of Medical Systems - Category: Information Technology Source Type: research
Esophageal cancer (EC) is considered a most common gastrointestinal malignant cancer in our world (1). It has a highly morbidity and mortality, more than 450,000 new cases of EC were diagnosed, and about 400,000 patients were died in each year (2). According to histological type, EC was classified two different forms, esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC) (3). Several reports revealed that ESCC is the main histological subtype of EC in developing countries (4).
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Tags: Original Article Source Type: research
More News: Cancer & Oncology | Carcinoma | Squamous Cell Carcinoma