Deficits in Ultrasonic Vocalization Development and Production following Neonatal Hypoxic Ischemic Insult.

This study examines the acute and long-term ultrasonic vocalization ability of mice after HI at PND 10. Pups were subjected to HI, sham, or naïve conditions; where in HI and sham surgeries the right common carotid artery was exposed, in the HI this artery was double ligated. The HI and sham pups were then exposed to 60 minutes of hypoxia. Naïve pups did not undergo surgery and were subjected to 60 minutes of room air. At 3 days following surgery, HI and sham pups vocalize less than nonsurgical naïve controls; yet "juvenile" mice of 6-8 weeks old that underwent HI at PND 10 vocalize less than sham and naïve mice. We conclude that HI injury has significant impact on later adult vocalization.
PMID: 31047922 [PubMed - as supplied by publisher]

Source: Behavioural Brain Research - April 28, 2019 Category: Neurology Authors: Doran SJ, Jandzinski M, Patrizz A, Trammel C, Sharmeen R, Mamun AA, Capozzi L, Reddy Venna V, Liu F, McCullough LD Tags: Behav Brain Res Source Type: research