Perinatal High Fat Diet Alters Development of GABAA Receptor Subunits in the Dorsal Motor Nucleus of the Vagus.

This study suggests that pHFD exposure arrests the development of synaptic GABAA a2/3 receptor subunits on DMV neurons, and that functional synaptic expression is maintained into adulthood, although cellular localization may differ. The tonic activation of slower GABAA a2/3 subunit-containing receptors implies such developmental changes may contribute to the observed decreased gastric motility. PMID: 31042399 [PubMed - as supplied by publisher]
Source: Am J Physiol Gastroi... - Category: Gastroenterology Authors: Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research