Characteristics associated with significantly worse quality of life in mycosis fungoides/S ézary syndrome from the Prospective Cutaneous Lymphoma International Prognostic Index (PROCLIPI) study.

CONCLUSION: HRQoL is significantly more impaired in newly diagnosed female patients with MF/SS and in those with alopecia. As Skindex-29 does not include existential questions on cancer which may cause additional worry and distress, a comprehensive validated CTCL specific questionnaire is urgently needed to more accurately assess disease-specific HRQoL among these patients. This article is protected by copyright. All rights reserved. PMID: 31049926 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research

Related Links:

CONCLUSIONS: Modafinil shows preliminary evidence of alleviating specific cognitive symptoms in MDD patients, especially in the short term. However, more research using placebo-controlled longitudinal designs is needed to assess the benefits of modafinil, as there are very few studies addressing modafinil and cognition in MDD. PMID: 31599501 [PubMed - in process]
Source: Journal of Clinical Psychiatry - Category: Psychiatry Tags: J Clin Psychiatry Source Type: research
Publication date: Available online 10 October 2019Source: Biosensors and BioelectronicsAuthor(s): Sungwook Park, Minsoo Kim, Dongkap Kim, Seok Ho Kang, Kwan Hyi Lee, Youngdo JeongAbstractIon-sensitive field-effect transistor (ISFET) as a biosensor facilitates a process of data-acquisition through label-free and real-time monitoring. Direct quantification of a biomarker in serum is challenging in ISFET biosensor since charged proteins in serum interfere transduction to electrical signals. Here, we report the fabrication of protein blocking layers (PBLs) with intended interfacial charges to minimize non-specific protein bind...
Source: Biosensors and Bioelectronics - Category: Biotechnology Source Type: research
This study explores the optimized conditions for the maximal prodigiosin production, characterization of prodigiosin, biomedical applications against therapeutically important diseases. Prodigiosin was extracted, purified using different solvents and the purified prodigiosin was characterized using FT-IR, UV–Vis Spectrometry and GC-MS analysis. The maximal production of prodigiosin was identified using different optimization methods. UV–Vis spectrophotometry showed the absorbance peak at 530 nm and the FT-IR result revealed prodigiosin contains most of the functional groups that are corresponding to the liter...
Source: Biocatalysis and Agricultural Biotechnology - Category: Biotechnology Source Type: research
Conclusion: Adjuvant therapy using S-1 is a cost-effective alternative compared to gemcitabine in patients with postoperative pancreatic cancer from the Chinese societal perspective. PMID: 31597496 [PubMed - as supplied by publisher]
Source: Expert Review of Pharmacoeconomics and Outcomes Research - Category: Health Management Tags: Expert Rev Pharmacoecon Outcomes Res Source Type: research
Authors: Moore Simas TA, Huang MY, Packnett ER, Zimmerman NM, Moynihan M, Eldar-Lissai A Abstract Objective: To assess healthcare resource utilization (HRU) and costs in children of mothers with and without postpartum depression (PPD). Methods: Administrative claims data from the IBM Watson Health MarketScan® Databases (2010-2016) were used. Women with live births (index date = delivery date) were identified and linked to their newborns. The mother-child pairs were divided into PPD and non-PPD exposure cohorts based on claims for depression, mood or adjustment disorders, or anxiety identified in t...
Source: Journal of Medical Economics - Category: Health Management Tags: J Med Econ Source Type: research
Publication date: Available online 9 October 2019Source: MethodsAuthor(s): Roberta Noberini, Camilla Restellini, Evelyn Oliva Savoia, Tiziana BonaldiAbstractAberrations in histone post-translational modifications (PTMs) have been implicated with the development of numerous pathologies, including cancer. Therefore, profiling histone PTMs in patient samples could provide information useful for the identification of epigenetic biomarkers, as well as the discovery of potential novel targets. While antibody-based methods have been traditionally employed to analyze histone PTM in clinical samples, mass spectrometry (MS) can prov...
Source: Methods - Category: Molecular Biology Source Type: research
ConclusionOur studies confirmed that PG exerts anti-ferroptosis and anti-tumor effects in vitro and in vivo through regulating miR-103a-3p/GLS2 axis, thereby highlighting its therapeutic potential in GC.
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 10 October 2019Source: Life SciencesAuthor(s): Heresh Moridi, Jamshid Karimi, Heidar Tavilani, Iraj Khodadadi, Amir Nader Emami RazaviAbstractAimsLong non-coding RNAs (LncRNAs) play central roles in the formation and development of gastric cancer (GC). The aim of this study was to evaluate the expression of PURPL and NONHSAT062994 and the relationship between their expressions with clinical characteristics in GC.Main methodsPURPL and NONHSAT062994 LncRNAs and p53 gene expression levels were analyzed both in 50 pairs of cancerous and adjacent noncancerous tissue samples in GC patients usin...
Source: Life Sciences - Category: Biology Source Type: research
In conclusion, Ab-PEG-Bi2Se3 may serve as an efficient PTT platform in combination with macrophage-mediated immunotherapy to improve antitumor efficacy.Graphical abstract
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
Publication date: 15 January 2020Source: Sensors and Actuators B: Chemical, Volume 303Author(s): Jian Hua Wang, Yao Ming Liu, Jian Bin Chao, Hui Wang, Yu Wang, ShaoMin ShuangAbstractA very simple schiff base fluorescent probe (NIS) was facilely prepared via a one-step, one-pot condensation reaction between 2, 3-naphthalenediamine and imidazole-2-carboxaldehyde. Among common biologically relevant metal ions, NIS can selectively recognize Cd2+ via ratiometric fluorescence signal. The chelation of NIS with the Cd2+ ions resulted in a fluorescence enhancement together with a blue shift (˜74 nm) in the emission maxima, ...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
More News: Alopecia | Cancer | Cancer & Oncology | Cutaneous T cell lymphoma | Depression | Dermatology | Lymphoma | Mycosis Fungoides | Pain | Skin | Study | T-cell Lymphoma | UK Health