One new sesquiterpene and one new iridoid derivative from Valeriana amurensis

Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Yang-Guo Xie, Xin-Cai Zhao, Syed Shams ul Hassan, Xiao-Yong Zhen, Ishaq Muhammad, Shi-kai Yan, Xing Yuan, Hui-liang Li, Hui-zi JinAbstractOne new sesquiterpene 1S, 3S, 4S, 7S 3,4-dihydroxy-bisabolol (1), one new iridoid amurensin A (2) and 10 known compounds were isolated from the whole plants of Valeriana amurensis. Their structures were established on the basis of extensive spectroscopic analysis and the absolute stereochemistry of compound 1 was assigned by X-ray diffraction analysis with Cu-Kα irradiation. All of compounds were evaluated for their inhibitory effects on NO production in LPS-induced RAW264.7 macrophages. Compound 12 displayed significant anti-inflammatory activity with IC50 value of 1.97 μM.Graphical abstract

Source: Phytochemistry Letters - May 4, 2019 Category: Chemistry Source Type: research