Causal Effects of Genetically Predicted Cardiovascular Risk Factors on Chronic Kidney Disease: A Two-Sample Mendelian Randomization Study

Causal Effects of Genetically Predicted Cardiovascular Risk Factors on Chronic Kidney Disease: A Two-Sample Mendelian Randomization Study Hui-Min Liu1,2, Qin Hu3, Qiang Zhang4, Guan-Yue Su5, Hong-Mei Xiao1,2, Bo-Yang Li1,2, Wen-Di Shen1,2, Xiang Qiu1,2, Wan-Qiang Lv1,2 and Hong-Wen Deng1,2,6* 1Center of System Biology and Data Information, School of Basic Medical Science, Central South University, Changsha, China 2Center of Reproductive Health, School of Basic Medical Science, Central South University, Changsha, China 3Kangda College of Nanjing Medical University, Nanjing, China 4College of Public Health, Zhengzhou University, Zhengzhou, China 5Institute of Biomedical Engineering, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu, China 6Tulane Center of Bioinformatics and Genomics, Department of Biostatistics and Data Science, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, United States Observational studies have demonstrated that cardiovascular risk factors are associated with chronic kidney disease (CKD). However, these observational associations are potentially influenced by the residual confounding, including some unmeasured lifestyle factors and interaction risk factors. Two-sample mendelian randomization analysis was conducted in this study to evaluate whether genetically predicted cardiovascular risk factors have a causal effect on the risk of CKD. We selected genetic variant...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research

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Publication date: Available online 24 May 2019Source: World Journal of Acupuncture - MoxibustionAuthor(s): Shuang ZHAO, Meng-lu QIN, Wen-jia WANG, Jing LIAbstractAllergic rhinitis (AR) is the frequently-encountered disease and commonly seen in clinic. Acupuncture-moxibustion therapy brings the significant therapeutic effects on it. In order to achieve the significant effects on AR, the relevant key factors should be determined definitely in treatment with acupuncture-moxibustion therapy. In the combination of the theoretic study with clinical practice, the authors expounded the key factors in acupuncture-moxibustion treatm...
Source: World Journal of Acupuncture Moxibustion - Category: Complementary Medicine Source Type: research
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Source: Chinese Herbal Medicines - Category: Complementary Medicine Source Type: research
ConclusionBBR can offer an anti-inflammatory effect and reverse the inhibition of CYP7A1 and CYP8B1 expression caused by LPS treatment, as well as induce the production of bile acids in liver, probably via MAPK signaling; However, treatment with BBR had no effect on the size of total bile acid pool.
Source: Chinese Herbal Medicines - Category: Complementary Medicine Source Type: research
In this study, we evaluated the antimicrobial activity of the extracts from herbal plant Persecaria pensylvanicum’s flower, leaf, stem and root. This plant is also known by a common name Pennsylvania smartweed. The antimicrobial effect of the extracts was tested using minimimum inhibitory concentration (MIC) and minimum bacteriocidal concentration (MBC) methods in comparison with tetracycline, a commercial antibiotic.ResultsWe found that extract from P. pensylvanicum kills bovine mammary glands pathogenic S. aureus strain Newbould 305. The minimum inhibitory concentration (MIC) breakpoints for extracts from flower, l...
Source: European Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research
Publication date: Available online 24 May 2019Source: Revista Española de Cardiología (English Edition)Author(s): Laura Galian-Gay, Blanca Gordon, Josep Ramón Marsal, Agnès Rafecas, Antonia Pijuan Domènech, Miguel Angel Castro, Maria T. Subirana Domènech, Carlos Sureda, Berta Miranda, Gerard Martí, David García-Dorado, Laura Dos SubiràAbstractIntroduction and objectivesAlthough pulmonary valve stenosis (PVS) is considered a low risk congenital heart disease, there have been reports of complications and the need for reintervention throughout follow-up. The aims ...
Source: Revista Espanola de Cardiologia - Category: Cardiology Source Type: research
Publication date: Available online 24 May 2019Source: Canadian Journal of CardiologyAuthor(s): Riina M. Kandolin, Christiane C. Wiefels, Cláudio Tinoco Mesquita, Aun-Yeong Chong, Paul Boland, David Glineur, Louise Sun, Rob S. Beanlands, Lisa M. MielniczukAbstractThis review describes the current evidence and controversies for viability imaging to direct revascularization decisions and the impact on patient outcomes. Balancing procedural risks and possible benefit from revascularization is a key question in patients with heart failure of ischemic origin (IHF). Different stages of ischemia induce adaptive changes in m...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Publication date: Available online 23 May 2019Source: Journal of Cancer PolicyAuthor(s): Steve Langton, Derek Lowe, Simon N Rogers, Annette Plüddemann, Clare BankheadAbstractBackgroundThe ‘two-week rule’ (TWR) fast-track cancer referral system for head and neck cancers was introduced by the UK government in 2000, to facilitate earlier diagnosis. However, little work has compared stage on diagnosis of cancer before and after the implementation of the system.Objectives•Describe the presentation of oral cancer in Merseyside from 1992-2012.•To evaluate whether stage on presentation has improved after...
Source: Journal of Cancer Policy - Category: Cancer & Oncology Source Type: research
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Source: Journal of Geriatric Oncology - Category: Cancer & Oncology Source Type: research
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Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 23 May 2019Source: Cancer CellAuthor(s): Ruidong Xue, Lu Chen, Chong Zhang, Masashi Fujita, Ruoyan Li, Shu-Mei Yan, Choon Kiat Ong, Xiwen Liao, Qiang Gao, Shota Sasagawa, Yanmeng Li, Jincheng Wang, Hua Guo, Qi-Tao Huang, Qian Zhong, Jing Tan, Lisha Qi, Wenchen Gong, Zhixian Hong, Meng LiSummaryWe performed genomic and transcriptomic sequencing of 133 combined hepatocellular and intrahepatic cholangiocarcinoma (cHCC-ICC) cases, including separate, combined, and mixed subtypes. Integrative comparison of cHCC-ICC with hepatocellular carcinoma and intrahepatic cholangiocarcinoma revealed that...
Source: Cancer Cell - Category: Cancer & Oncology Source Type: research
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