Associations of Symptomatic Knee Osteoarthritis With Histopathologic Features in Subchondral Bone

ConclusionSubchondral pathology was associated with symptomatic knee OA, independent of chondropathy and synovitis. Increased NGF expression in osteochondral channels and increased osteoclast density appear to be key features associated with bone pain in knee OA.

https://onlinelibrary.wiley.com/doi/abs/10.1002/art.40820?af=R

Source: Arthritis and Rheumatology - May 1, 2019 Category: Rheumatology Authors: Koji Aso, S. Mohsen Shahtaheri, Roger Hill, Deborah Wilson, Daniel F. McWilliams, David A. Walsh Tags: Original Article Source Type: research