Unveiling the Antifungal Potential of Two Iberian Thyme Essential Oils: Effect on C. albicans Germ Tube and Preformed Biofilms

Conclusion This study highlights the antifungal potential of two Iberian endemic thyme species: T. camphoratus and T. carnosus. Of relevance, the results demonstrated that both oils were able to inhibit the growth of Cryptococcus neoformans and several dermatophyte strains. Moreover, the oils were very effective in inhibiting C. albicans germ tube formation at concentrations well below the MIC and in a much higher extend than fluconazole, an antifungal drug widely used in the clinic. Finally, T. carnosus oil was more effective in decreasing yeast mitochondrial activity and disrupting preformed biofilms in C. albicans. Overall, our results point out promising anti-virulent effects for these oils, foreseeing a potential application in the management of disseminative candidiasis. Our findings add relevant information to the pharmacological activity of these species concomitantly providing new insights to their mechanism of action and reinforcing the use of thyme plants as topical antiseptics and disinfectants, since toxicity towards keratinocytes was absent at most of the bioactive concentrations. In addition to the relevant antifungal activity, both thymes have a very good essential oil yield, which increases their commercial interest and industrial potential. Overall, our results raise awareness on species poorly recognized and valued, thus paving the way for a better industrial exploitation of these plants namely in the pharmaceutical field. Author Contributions MA and MG...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research