Regulation of Wnt Singaling Pathway by Poly (ADP-Ribose) Glycohydrolase (PARG) Silencing Suppresses Lung Cancer in Mice Induced by Benzo(a)pyrene Inhalation Exposure

In conclusion, in the development of lung cancer induced by BaP, the expression of Wnt ligands are up-regulated, which is consistent with current understanding of the role of this pathway. Additionally, PARG gene silencing may regulate the phosphorylation level of proteins to stabilize the expression of Wnt2b, possibly inhibiting the ability of Wnt/β-catenin pathway to drive lung cancer progression as shown in the schematic model in Figure 6. The mechanism how PARG gene silencing affects the expression of Wnt5 remains to be futher explored. Understanding of the unresolved issue will contribute to the development of applications of PARG for cancer therapy. Lung cancer is one of the world’s most serious threats to human health and has become a global public health problem (Siegel et al., 2018). Therefore, studying the mechanisms of lung cancer provides increased understanding that is relevant to its diagnosis and treatment. Though epigenetic modification is extensive, basic and reversible, its theory and results are gradually being applied to the diagnosis and treatment of cancer (Dawson and Kouzarides, 2012). In this study, it is shown that PARG gene silencing can prevent the occurrence of lung cancer induced by BaP. Our results demonstrate that PARG may be a target for the diagnosis and treatment of lung cancer. Furthermore, the inhibition of Wnt ligands may inhibit lung cancer. These results provide a new potential approach for the treatment of lung cancer. In ...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research