The role of inflammatory programmed cell death in gastrointestinal cancer and immune responses to intestinal microbial infection

Publication date: Available online 3 May 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Cheng-Bei Zhou, Jing-Yuan FangAbstractInflammatory programmed cell death, also called pyroptosis, is mediated by multiple inflammasomes which can recognize danger signals and activate the secretion of pro-inflammatory cytokines like IL-181 and IL-1β.2 It can induce cancer cell death within the gastrointestinal tract. NLRs,3 AIM2,4 GSDM5 family play important roles in pyroptosis signaling pathways in intestinal cancer such as gastric cancer, colitis-associated colorectal cancer and esophageal cancer, etc. Furthermore, several inflammasomes are elucidated to be involved in mucosal innate immune responses and modulate specific enteric pathogens infection. Precise modulation of inflammasome activation and exploration of potential diagnostic markers can contribute to the diagnosis, prevention and treatment of intestinal tumors and inflammatory or infectious disorders in human patients in the near future.
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - Category: Cancer & Oncology Source Type: research