Myeloid-Derived Suppressor Cells: Ductile Targets in Disease

Discussion MDSCs violently emerge in pathological conditions in an attempt to limit potentially harmful immune and inflammatory responses. Mechanisms supporting their expansion and survival are deeply investigated in cancer, in the perspective to reactivate specific antitumor responses and prevent their contribution to disease evolution. These findings will likely contribute to improve the targeting of MDSCs in anticancer immunotherapies, either alone or in combination with immune checkpoint inhibitors. New evidence indicates that the expansion of myeloid cell differentiation in pathology is subject to fine-tuning, as its alterations may support either immunosuppression or autoimmunity. This pathological plasticity is supported by evidence indicating that common MDSC-associated targets may be specularly targeted in autoimmunity vs. cancer (12), and there is now hope that understanding autoimmune mechanisms might serve as a lesson for the development of new anticancer therapies. The functional plasticity and therapeutic ductility of these cells (Figure 2) suggest that while MDSC inhibition might succeed as anticancer treatment, their induction is expected to provide therapeutic benefit in autoimmune diseases. FIGURE 2 Figure 2. Schematic role of MDSCs in pathology. Immunological stress induces the expansion of MDSCs that play different roles depending on distinct pathological and microenvironmental contexts. MDSCs are characterized by the strong ability to suppress ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research

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