TLR3 Ligand PolyI:C Prevents Acute Pancreatitis Through the Interferon- β/Interferon-α/β Receptor Signaling Pathway in a Caerulein-Induced Pancreatitis Mouse Model

In this study, we have found that polyI:C pretreatment prevents caerulein-induced pancreas edema, neutrophil infiltration, the accumulation of ROS, and inflammatory gene expression in the AP mice models. PolyI:C-triggered IFN-β production and downstream IFNAR signaling activation are required for the suppressive effect of polyI:C in the caerulein-induced AP model. Our study has not only demonstrated the protective role of polyI:C in limiting AP, but has also suggested a potential application of TLR3 ligands in the treatment of AP. Materials and Methods Mice and Reagents Ifnb−/− mice and Ifnar1−/− mice were gifted from Genhong Cheng Laboratory (University of California, CA, USA). Tlr4−/− mice were purchased from Model Animal Research Center (Nanjing, China). Wild-type (WT) C57BL/6 mice were acquired from Vital River Laboratory Animal Technology (Beijing, China). All the mice were maintained in the specific pathogen-free (SPF) environment at Suzhou Institute of Systems Medicine (ISM) under a controlled temperature (25°C) and a 12-h day/night cycle. Male 8–10-week-old mice were used in all the experimental AP mice models. All mice experiments were undertaken in accordance with the US National Institutes of Health Guide for the Care and Use of Laboratory Animals, with the approval of the Scientific Investigation Board of ISM, Suzhou. Antibodies against HO-1 (#70081) and GAPDH (#5174) were from Cell Signaling Technology (Danver...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research

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CONCLUSIONS In a summary, by inhibiting the STAT3 activation, esculetin shows potential anticancer effects against the laryngeal cancer. PMID: 31630150 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
CONCLUSIONS: Despite the slight increases in the 10-year observation period a stable trend cannot be assumed. However, this study might be useful as baseline for other studies on SDM implementation. PMID: 31629688 [PubMed - as supplied by publisher]
Source: Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen - Category: Health Management Tags: Z Evid Fortbild Qual Gesundhwes Source Type: research
CONCLUSION: Ultrastructural changes in rat liver tissue in conditions of obstructive jaundice may be reversible after restoration of drainage. On the other hand, ultrastructural changes in renal tissue in cases of prolonged jaundice are irreversible even if the internal drainage is restored. KEY WORDS: Bile Duct, Liver, Kidney, Obstructive Jaundice. PMID: 31630139 [PubMed - as supplied by publisher]
Source: Annali Italiani di Chirurgia - Category: Surgery Tags: Ann Ital Chir Source Type: research
His research brought an end to radical mastectomy, and he pioneered the design and implementation of large-scale multi-institutional randomized clinical trials.Medscape Medical News
Source: Medscape Hematology-Oncology Headlines - Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news
This study assessed the effects of the incorporation of Lactobacillus acidophilus LA-05 or Bifidobacterium animalis ssp. lactis BB-12 in the content and bioaccessibility of phenolics in red pitaya pulp. The oxygen radical absorbance capacity (ORAC) of the dialyzed (bioaccessible) fraction of red pitaya pulp fermented by these probiotics was also assessed. After 48 h of cultivation in red pitaya pulp, the pH and sugar contents decreased, while organic acids and viable counts of the tested probiotics increased (p 
Source: Food Research International - Category: Food Science Source Type: research
This article also intends to review advances in the botanical, phytochemical, pharmacological studies and industrial applications of R. tomentosa, which will provide a useful bibliography for further investigations and applications of R. tomentosa in medicines and foods.
Source: Food Chemistry - Category: Food Science Source Type: research
Publication date: Available online 21 October 2019Source: Food ChemistryAuthor(s): Khiena Brainina, Aleksey Tarasov, Ekaterina Khamzina, Natalia Stozhko, Marina VidrevichAbstractA new version of the hybrid potentiometric method (HPM) for evaluating the antioxidant activity (AOA) of fruits and vegetables, which we called contact (CHPM), is proposed. A screen-printed electrode pair coated by a membrane impregnated with a mediator serves as a sensor system. The potential shift, which is observed when the sensor system is exposed to the sample slice is used as a source of information. CHPM provides reproducible and correct res...
Source: Food Chemistry - Category: Food Science Source Type: research
The current clinical study is aimed at evaluating the clinical relevance of an innovative device (called CyPaM2 device) that for the first ...
Source: Journal of the Optical Society of America A - Category: Physics Authors: Source Type: research
This study found that the incorporation of flax fibres into PHBV matrix provides a benefit to the green composites with enhanced biodegradability.Graphical abstract
Source: Biocatalysis and Agricultural Biotechnology - Category: Biotechnology Source Type: research
Source: Cancer Management and Research - Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research
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