Fecal Metabolomics and Potential Biomarkers for Systemic Lupus Erythematosus

In this study, we analyzed the metabolic profiling of fecal samples from SLE patients and healthy controls based on ultra-high-performance liquid chromatography equipped with mass spectrometry for exploring the potential biomarkers of SLE. The results showed that 23 differential metabolites and 5 perturbed pathways were identified between the two groups, including aminoacyl-tRNA biosynthesis, thiamine metabolism, nitrogen metabolism, tryptophan metabolism, and cyanoamino acid metabolism. In addition, logistic regression and ROC analysis were used to establish a diagnostic model for distinguishing SLE patients from healthy controls. The combined model of fecal PG 27:2 and proline achieved an area under the ROC curve of 0.846, and had a good diagnostic efficacy. In the present study, we analyzed the correlations between fecal metabolic perturbations and SLE pathogenesis. In summary, we firstly illustrate the comprehensive metabolic profiles of feces in SLE patients, suggesting that the fecal metabolites could be used as the potential non-invasive biomarkers for SLE. Introduction Systemic lupus erythematosus (SLE) is an autoimmune disease with persistent inflammation that affects multiple organ systems, characterized by high morbidity and low quality of life. The etiological factors and pathogenesis of SLE are still not completely understood (1). However, a lot of evidences suggest that the gut microbiome takes an important role in inflammatory and autoimmune diseases by...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research