Linking Cell Dynamics With Gene Coexpression Networks to Characterize Key Events in Chronic Virus Infections

This study was carried out in accordance with the recommendations of the Guidelines of the Basel Declaration and from the Generalitat de Catalunya (project number 9422). The protocol was approved by the ethical committee for animal experimentation (CEEA-PRBB, Spain; permit license number JMR-16-0046). Author Contributions JA and AM designed the study. MP, GR, VC, and CS performed experiments. MP, AE-C, YS, SH, and IG-V performed the bioinformatic analyses of the RNA-Seq data sets including WGCNA and DCQ. MP and JA accessed the bioinformatic data output. JA, MP, GB, and AM interpreted the data and wrote the manuscript. All authors read and approved the final manuscript. Funding This work is supported by a grant from the Spanish Ministry of Economy, Industry and Competitiveness and FEDER grant no. SAF2016-75505-R (AEI/MINEICO/FEDER, UE) and the María de Maeztu Programme for Units of Excellence in R&D (MDM-2014-0370). GB and AM are also supported by the Russian Science Foundation (grant 18-11-00171). AE-C and SH are also supported by Instituto de Salud Carlos III (ISCIII) grant from the Spanish Ministry of Economy, Industry and Competitiveness and FEDER grant no. PT17/0009/0019. YS is supported by the Edmond J. Safra Center for Bioinformatics, Tel Aviv University and Shulamit Aloni Scholarship, Ministry of Science and Technology. IG-V is supported by European Research Council (637885). Conflict of Interest Statement The authors declare that the research was...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research