Linking Cell Dynamics With Gene Coexpression Networks to Characterize Key Events in Chronic Virus Infections

Linking Cell Dynamics With Gene Coexpression Networks to Characterize Key Events in Chronic Virus Infections Mireia Pedragosa1†, Graciela Riera1†, Valentina Casella1, Anna Esteve-Codina2,3, Yael Steuerman4, Celina Seth1, Gennady Bocharov5,6, Simon Heath2,3, Irit Gat-Viks4, Jordi Argilaguet1* and Andreas Meyerhans1,7* 1Infection Biology Laboratory, Department of Experimental and Health Sciences (DCEXS), Universitat Pompeu Fabra, Barcelona, Spain 2CNAG-CRG, Center for Genomic Regulation (CRG), Barcelona Institute of Science and Technology, Barcelona, Spain 3Universitat Pompeu Fabra, Barcelona, Spain 4Cell Research and Immunology Department, Tel Aviv University, Tel Aviv, Israel 5Marchuk Institute of Numerical Mathematics, Russian Academy of Sciences, Moscow, Russia 6Institute for Personalized Medicine, Sechenov First Moscow State Medical University, Moscow, Russia 7Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain The host immune response against infection requires the coordinated action of many diverse cell subsets that dynamically adapt to a pathogen threat. Due to the complexity of such a response, most immunological studies have focused on a few genes, proteins, or cell types. With the development of “omic”-technologies and computational analysis methods, attempts to analyze and understand complex system dynamics are now feasible. However, the decomposition of transcriptomic data sets generated...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research

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CONCLUSION: Pregnancy outcomes after hysteroscopic placement of a microinsert for hydrosalpinx management before embryo transfer were comparable to those following laparoscopic proximal tubal occlusion or salpingectomy. However, caution is advised regarding microinsert placement for hydrosalpinges before proceeding with assisted reproductive technology. PMID: 32224160 [PubMed - as supplied by publisher]
Source: Journal of Obstetrics and Gynaecology Canada : JOGC - Category: OBGYN Tags: J Obstet Gynaecol Can Source Type: research
Authors: Zhou S, Wei J, Wang Y, Liu X Abstract Hepatocellular carcinoma (HCC) is a leading cause of cancer-associated mortality worldwide. Despite clinical advances, the survival rate of patients with HCC remains low, as most patients are diagnosed with HCC when they are already at the advanced stage. Certain circular RNAs (circRNAs) are closely associated with the development of liver cancer. In the present study, a circRNA array was performed to screen differentially expressed circRNAs in HCC tissues. The further analysis focused on the newly identified circRNA_101237, the host gene of which, cyclin-dependent kin...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Authors: Li L, Zheng Y, Zheng Q, Jiang J Abstract The present study aimed to investigate the antiproliferative effect of embryonic stem cell-conditioned medium (ESC-CM) on the mouse liver cancer Hepa1-6 cells in vitro. Furthermore, in order to elucidate the underlying molecular mechanism, the microRNAs (miRNAs) in ESC-CM associated with the inhibition of Hepa1-6 proliferation were identified. Following the co-culture of ESC-CM and Hepa1-6 in Transwell chambers, the proliferation, cell cycle, apoptosis and associated protein expression were determined in Hepal-6 cells. Moreover, miRNA array analysis was employed to ...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
In spite of the recent approval of new promising targeted therapies, the clinical outcome of patients with acute myeloid leukemia (AML) remains suboptimal, prompting the search for additional and synergistic therapeutic rationales. It is increasingly evident that the bone marrow immune environment of AML patients is profoundly altered, contributing to the severity of the disease but also providing several windows of opportunity to prompt or rewire a proficient antitumor immune surveillance. In this Review, we present current evidence on immune defects in AML, discuss the challenges with selective targeting of AML cells, an...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
[Premium Times] Amidst unrelenting criticism of alleged poor political leadership at the highest level in the fight against the coronavirus pandemic in Nigeria, the presidency has listed "some of the reactions by the agencies and trained experts, under the leadership of President Buhari' in the fight against the virus.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Conclusions: Older adults who begin using cannabis are likely using for what they perceive to be medicinal purposes for a range of issues. However, they receive minimal guidance from their family physicians and instead obtain information from non-clinician sources.Clinical implications: Cannabis screening should be included in geriatric assessments and medicine reconciliation. Continuing education for clinicians needs to address knowledge gaps about cannabis use among older adults. PMID: 32223535 [PubMed - as supplied by publisher]
Source: Clinical Gerontologist - Category: Geriatrics Tags: Clin Gerontol Source Type: research
[Daily Trust] As the COVID-19 pandemic continues its disruptive spread with far-reaching implications for business efficiency nationwide, an entrepreneurship and small business expert, Dr Timi Olubiyi, has projected that the nation's unemployment rate would increase unless government supports businesses with remedial fiscal incentives to mitigate the impaxct of the viral disease on their operations
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Researchers at University of Arizona College of Medicine have invented a new device that provides oxygen and support for people that need respiratory assistance for the COVID-19 outbreak. The device is a small-scale, low-pressure rebreathing system that removes carbon dioxide and introduces a mixture of helium and oxygen to the respiratory airways. The device could help a coronavirus patient earlier in the process and might reduce the need for ventilators. Phoenix-based startup S aiOx licensed…
Source: Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
Trump says personal protective gear has nearly run out; Florida, Georgia, Mississippi ordered to shelter in place; record daily fatalities in UK. Follow the latest updates.At a glance: summary of key eventsWimbledon cancelled due to coronavirus crisisAustralia coronavirus – latest updatesSee all of our coronavirus coverage5.54amBSTThe Chinese city of Shenzhen has banned the eating of dogs and cats as part of a wider clampdown on the wildlife trade since the emergence of the new coronavirus, Reuters reports.Scientists suspect the coronavirus passed to humans from animals. Some of the earliest infections were found in ...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak UK news World news Science Infectious diseases Middle East and North Africa South Africa Russia China Japan Asia Pacific Europe Medical research Microbiology Source Type: news
NIEHS research on the virus aims to reveal structures suitable for targeted development of potential vaccines and treatments. (read more)
Source: Environmental Factor - NIEHS Newsletter - Category: Environmental Health Source Type: news
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