Is the Complement Protein C1q a Pro- or Anti-tumorigenic Factor? Bioinformatics Analysis Involving Human Carcinomas
This study is an important step forward in highlighting C1q as a new prognostic candidate biomarker for a range of carcinomas. Methods Oncomine Database Analysis The expression levels of C1QA, C1QB, and C1QC genes in various carcinomas were analyzed using Oncomine (www.oncomine.org), a cancer microarray database and web-based data mining platform from genome-wide expression analyses (22, 23). We compared the differences in mRNA level between normal tissue and carcinoma. The mRNA expression levels in neoplastic tissues compared to the healthy tissues were obtained as the parameters of p-value 2, and gene ranking in the top 10%. Information about the dataset used in this study is summarized in Supplementary Table 1. Kaplan-Meier Plotter Database Analysis A Kaplan-Meier plotter database can be used to assess the effect of 54,675 genes on survival using 10,461 carcinoma samples (5,143 breast, 1,816 ovarian, 2,437 lung, and 1,065 gastric cancer patients with a mean follow-up of 69/40/49/33 months) using probe sets on the HGU133 Plus 2.0 array from Gene Expression Omnibus (GEO). For other human carcinoma, a total of 3,439 patients with RNA HiSeq data from The Cancer Genome Atlas (TCGA) cohort were collected. The prognostic significance of C1QA, C1QB, and C1QC expression and survival in several carcinomas was analyzed by Kaplan-Meier plotter (www.kmplot.com/analysis/) (24). The hazard ratio with 95% confidence intervals and logrank p-value was also computed. Immunohistochemica...
Several human polyomaviruses, including Merkel cell polyomavirus, have been isolated on the skin. Which are associated with cutaneous disease, and what do we know about their molecular mechanisms?The British Journal of Dermatology
(Wiley) Survivors of childhood brain tumors who received radiotherapy and were very young at the time of diagnosis may experience cognitive and socioeconomic burdens decades after treatment, according to a study published early online in CANCER, a peer-reviewed journal of the American Cancer Society. Interventions such as cognitive therapies and educational and occupational services may be needed to mitigate such long-term effects.
CONCLUSIONS: It is recommended that the 5 Objects Test be used for assessing persons in primary care, including those from different linguistic backgrounds or with limited language use. Delayed recall scores are especially recommended given the lack of association with demographic variables. PMID: 31227658 [PubMed - in process]
If you or someone close to you have an autoimmune condition such as rheumatoid arthritis, lupus, Hashimoto’s thyroiditis, Crohn’s disease or ulcerative colitis, along with about 195 others, there are a number of steps you can take that reduce, even eliminate the autoimmune inflammation damaging your organs. (Unfortunately, some forms of autoimmune damage cannot be reversed. Autoimmune loss of pancreatic beta cells that lead to type 1 diabetes, Hashimoto’s thyroiditis that damages the thyroid gland, or autoimmune hepatitis that can lead to cirrhosis. for example, cannot be reversed even if the autoimmune p...
British Journal of Cancer, Published online: 24 June 2019; doi:10.1038/s41416-019-0495-5The role of mouse tumour models in the discovery and development of anticancer drugs
British Journal of Cancer, Published online: 24 June 2019; doi:10.1038/s41416-019-0500-zObesity, abdominal obesity and subsequent risk of kidney cancer: a cohort study of 23.3 million East Asians
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