Is the Complement Protein C1q a Pro- or Anti-tumorigenic Factor? Bioinformatics Analysis Involving Human Carcinomas
This study is an important step forward in highlighting C1q as a new prognostic candidate biomarker for a range of carcinomas. Methods Oncomine Database Analysis The expression levels of C1QA, C1QB, and C1QC genes in various carcinomas were analyzed using Oncomine (www.oncomine.org), a cancer microarray database and web-based data mining platform from genome-wide expression analyses (22, 23). We compared the differences in mRNA level between normal tissue and carcinoma. The mRNA expression levels in neoplastic tissues compared to the healthy tissues were obtained as the parameters of p-value 2, and gene ranking in the top 10%. Information about the dataset used in this study is summarized in Supplementary Table 1. Kaplan-Meier Plotter Database Analysis A Kaplan-Meier plotter database can be used to assess the effect of 54,675 genes on survival using 10,461 carcinoma samples (5,143 breast, 1,816 ovarian, 2,437 lung, and 1,065 gastric cancer patients with a mean follow-up of 69/40/49/33 months) using probe sets on the HGU133 Plus 2.0 array from Gene Expression Omnibus (GEO). For other human carcinoma, a total of 3,439 patients with RNA HiSeq data from The Cancer Genome Atlas (TCGA) cohort were collected. The prognostic significance of C1QA, C1QB, and C1QC expression and survival in several carcinomas was analyzed by Kaplan-Meier plotter (www.kmplot.com/analysis/) (24). The hazard ratio with 95% confidence intervals and logrank p-value was also computed. Immunohistochemica...
Publication date: Available online 8 July 2020Source: International Journal of Pediatrics and Adolescent MedicineAuthor(s): Halszka Kamińska, Anna Kostera-Pruszczyk, Anna Potulska-Chromik, Bożena Werner
Authors: Dutra JDM, Lisboa QC, Ferolla SM, Carvalho CMML, Mendes CCM, Ferrari TCA, Couto CA Abstract Some epidemiological evidence suggests an inverse correlation between non-alcoholic fatty liver disease (NAFLD) frequency and vitamin D levels. Likewise, a beneficial effect of vitamin D on diabetes mellitus (DM) and insulin resistance has been observed, but this is an unsolved issue. Thus, we aimed to investigate the prevalence of hypovitaminosis D in a NAFLD Brazilian population and its association with disease severity and presence of comorbidities. In a cross-sectional study, the clinical, biochemical and histo...
Authors: Sánchez-Cuesta A, Cortés-Rodríguez AB, Navas-Enamorado I, Lekue JA, Viar T, Axpe M, Navas P, López-Lluch G Abstract Ubiquinol, the reduced form of Coenzyme Q10 (CoQ10), is a key factor in bioenergetics and antioxidant protection. During competition, professional soccer players suffer from considerable physical stress causing high risk of muscle damage. For athletes, supplementation with several antioxidants, including CoQ10, is widely recommended to avoid oxidative stress and muscle damage. We performed an observational study of plasma parameters associated with CoQ10 levels in...
Publication date: Available online 9 July 2020Source: Pregnancy HypertensionAuthor(s): Amanda Henry, Clare Arnott, Angela Makris, Gregory Davis, Annemarie Hennessy, Amanda Beech, Franziska Pettit, Caroline SE Homer, Maria E. Craig, Lynne Roberts, Jon Hyett, Georgina Chambers, Oisin Fitzgerald, Megan Gow, Linda Mann, Daniel Challis, Marianne Gale, Annette Ruhotas, Emilee Kirwin, Elizabeth Denney-Wilson
From English pubs to the Spanish seaside, mini-lockdowns are cropping up all over the world as countries face fresh clusters of infection.
Exercise capacity increased after patients with pulmonary hypertension associated with interstitial lung disease were treated with the vasodilator for 16 weeks, new research shows.Medscape Medical News
Publication date: Available online 9 July 2020Source: Saudi Pharmaceutical JournalAuthor(s): Saranya Rameshbabu, Safia A. Messaoudi, Zeyad Ibrahim Alehaideb, Mohammed Syed Ali, Anuradha Venktraman, Hala Alajmi, Hamad Al-Eidi, Sabine Matou-Nasri
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Publication date: Available online 8 July 2020Source: Journal of Geriatric OncologyAuthor(s): Vittorio Gebbia, Marzia Mare, Stefano Cordio, Maria Rosaria Valerio, Dario Piazza, Roberto Bordonaro, Alberto Firenze, Dario Giuffrida
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