Inhibition of Period Gene Expression Causes Repression of Cell Cycle Progression and Cell Growth in the Bombyx mori Cells
Conclusion
Knockdown of BmPer expression in Bombyx mori blocked the BmN cell cycle, decreased nuclear size, accelerated apoptosis and autophagy, and inhibited cell proliferation.
Author Contributions
S-QX and J-FQ conceived this project. XL, J-FQ, W-ZC, X-FL, HT, and Y-HS performed the research. XL, J-FQ, and S-QX analyzed the data and wrote the manuscript. All authors participated in the revision of this manuscript.
Funding
This work was supported by the National Natural Science Foundation of China (Grant No. 31672492), the Provincial Key R&D Program of Jiangsu (Grant No. BE2015317), the China Agriculture Research System (CARS) (Grant No. CARS-22), and the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD), Postgraduate Research and Practice Innovation Program of Jiangsu Province (Grant No. KYCX18_2521). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The manuscript was edited by a native English speaker of International Science Editing Scientific Services.
Conflict of Interest Statement
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Supplementary Material
The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fphys.2019.00537/full#supplementary-material
References
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Source: Frontiers in Physiology - Category: Physiology Source Type: research
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