Circulating Tumor Necrosis Factor Alpha May Modulate the Short-Term Detraining Induced Muscle Mass Loss Following Prolonged Resistance Training

Conclusion Following a prolonged period of RT in young healthy individuals, muscle mass and strength were increased although there were no effects on the specific force of muscle or on systemic levels of TNFα. Furthermore, following a period of short-term detraining, muscle mass and strength were significantly reduced with muscle mass remaining significantly above baseline values following the conclusion of the detraining period. Changes in TNFα were significantly correlated with the reductions in muscle mass following detraining compared to post-training. TNFα may play a part in the detraining induced loss of muscle mass following a period of RT. However, further work is needed to corroborate this and the mechanisms by which this may occur are currently unknown. Ethics Statement This study was carried out in accordance with the recommendations of Manchester Metropolitan University Cheshire Campus ethics committee with written informed consent from all subjects. All subjects gave written informed consent in accordance with the Declaration of Helsinki. The protocol was approved by the Manchester Metropolitan University Cheshire Campus ethics committee. Author Contributions GM, CM, KW, AB, and GO conceived and planned the experiments, supervised the training sessions and contributed to the final version of the manuscript. GM with the support of GO performed all the experiments, statistical analyses, and wrote the manuscript. Conflict of Interest State...
Source: Frontiers in Physiology - Category: Physiology Source Type: research