Reducing Anesthetic Complications in Children Undergoing Tonsillectomies (REACT) With Albuterol

This randomized clinical trial evaluates the effect of preoperative administration of albuterol vs placebo on the rates of perioperative respiratory adverse events in young children undergoing tonsillectomy.
Source: JAMA Pediatrics - Category: Pediatrics Source Type: research

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ConclusionDexmedetomidine and midazolam at single minimum dosages had equal effectiveness to prevent ED in children without delaying emergence time, when administered at the end of surgery. With regards to postoperative analgesic efficacy, although dexmedetomidine showed statistically significant higher analgesic effect than midazolam, further clinical investigations are needed to validate our findings.
Source: Journal of Anesthesia - Category: Anesthesiology Source Type: research
In this study, 180 patients were randomized to 1 of the 6 groups: bupivacaine infiltration, lidocaine infiltration, normal saline infiltration, bupivacaine packing, lidocaine packing, and normal saline packing. Pain caused by speaking, swallowing, and on rest was assessed using VAS at 4, 8, 12, 16 hours, and at discharge. Results Significant analgesia was obtained in patients who received bupivacaine infiltration and packing compared with placebo (p 
Source: International Archives of Otorhinolaryngology - Category: ENT & OMF Authors: Tags: Original Research Source Type: research
CONCLUSION: This study demonstrates the clinical advantage and the simple technique of oral transmucosal DEX premedication for emergence agitation in preschool children undergoing tonsillectomy under sevoflurane anesthesia compared with saline placebo. TRIAL REGISTRATION: Clinical Trials.gov trial registry: NCT02720705. PMID: 31672419 [PubMed - as supplied by publisher]
Source: Revista Brasileira de Anestesiologia - Category: Anesthesiology Tags: Rev Bras Anestesiol Source Type: research
TUESDAY, Oct. 22, 2019 -- One-third of children undergoing tonsillectomies can do so without using opioids to manage pain, according to a study presented at the annual meeting of the American Society of Anesthesiologists, held from Oct. 19 to 23 in...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
CONCLUSION: Oropharyngeal papillomas, when present, can be found incidentally during examination of the oropharynx for other symptoms. Office-based biopsy and KTP laser is a safe and efficient means of identifying and removing most oropharyngeal papillomas. PMID: 31581834 [PubMed - as supplied by publisher]
Source: Ear, Nose and Throat Journal - Category: ENT & OMF Authors: Tags: Ear Nose Throat J Source Type: research
Conclusion: Intravenous dexmedetomidine infusion at ED50 (0.13 μg/kg) or ED95 (0.30 μg/kg) during induction for 10 min can prevent half or almost all EA after sevoflurane and remifentanil anesthesia during pediatric tonsillectomy and adenoidectomy.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
This article addresses principles to prevent or manage challenging conditions such as airway fires, anatomically difficult airways, and post-tonsillectomy hemorrhage. Discussion includes rationales for the use of simulation and resilience engineering principles to achieve the safest patient care.
Source: Otolaryngologic clinics of North America - Category: ENT & OMF Authors: Source Type: research
To the Editor Perturbations of the respiratory system are common in children during general anesthesia, especially following tonsillectomy. Many complications (mild desaturations and airway obstruction) are relatively benign and easily remedied, although some, such as laryngospasm and bronchospasm, are severe and lead to rapid escalation of care in the perioperative environment. Fortunately, severe complications during pediatric anesthesia are uncommon. This rarity makes them hard to study owing to the prohibitive sample size needed to power such studies. Consequently (and to improve statistical efficiency), investigators ...
Source: JAMA Pediatrics - Category: Pediatrics Source Type: research
This study is a retrospective cohort study performed at a tertiary care academic children's hospital. 166 pediatric patients (aged 1–16 years) who underwent tonsillectomy with or without adenoidectomy were for review. Seventy-four patients received intraoperative intravenous acetaminophen (intervention cohort), while ninety-two patients served as our control and did not receive any intraoperative intravenous acetaminophen. Perioperative (intraoperative and postoperative) morphine use was our primary outcome measure. Rate of adverse events in the post anesthesia care unit and time for discharge readiness were second...
Source: American Journal of Otolaryngology - Category: Endocrinology Source Type: research
ConclusionThis study demonstrates the clinical advantage and the simple technique of oral transmucosal DEX premedication for emergence agitation in preschool children undergoing tonsillectomy under sevoflurane anesthesia compared with saline placebo.Trial registrationClinical Trials.gov trial registry: NCT02720705.ResumoObjetivosA agitação ao despertar da anestesia é um comportamento negativo comumente registrado após amigdalectomia pediátrica. Avaliamos a eficácia da pré-medicação com dexmedetomidina via transmucosa oral no pré-operatório sobre a...
Source: Brazilian Journal of Anesthesiology - Category: Anesthesiology Source Type: research
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