Tailoring the Approach to Embolic Stroke of Undetermined Source

This narrative review examines the existing evidence of the differing response of embolic stroke of undetermined source to anticoagulation therapy and hypothesizes about pathophysiological factors that may underlie such variations.
Source: JAMA Neurology - Category: Neurology Source Type: research

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Background and Objectives: The benefit of tissue plasminogen activator (tPA) in acute ischemic stroke is time dependent. A 15-minute decrease in door-to-needle (DTN) time has been associated with increased odds of ambulating independently, faster discharge, and decreased odds of death. We investigated common causes of delay in DTN times in a community hospital setting in order to identify areas for improvement. Methods: A retrospective medical record review was conducted at a 574-bed community hospital. This included 100 patients who received tPA from 2016 to 2019. Time segments were classified a priori to reflect key...
Source: Quality Management in Healthcare - Category: Health Management Tags: Original Research Source Type: research
Background: Spasticity is common among patients with stroke. Repetitive peripheral magnetic stimulation (rPMS) is a painless and noninvasive therapy that is a promising approach to reducing spasticity. However, the central mechanism of this therapy remains unclear. Changes in cortical activity and decreased spasticity after rPMS intervention require further exploration. The aim of this study was to explore the electroencephalography (EEG) mu rhythm change and decrease in spasticity after rPMS intervention in patients with stroke.Materials and methods: A total of 32 patients with spasticity following stroke were recruited i...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Conclusion: The longitudinal length of the infarcted lesion along the perforating artery predicts END in cases of acute SSI without any relevant artery stenosis.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Conclusion: factors such as severe stroke, dysphagia, advanced age, male gender, coronary heart disease, lower Glasgow coma scale score, use of mechanical ventilation for more than 48 hours, and aspiration of colonized gastric juice were associated with aspiration pneumonia.
Source: Revista CEFAC - Category: Speech-Language Pathology Source Type: research
Conditions:   Stroke;   Aphasia;   Anomia Interventions:   Other: iTALKbetter: deterministic;   Other: iTALKbetter: reactive Sponsor:   University College, London Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Stroke;   CVA (Cerebrovascular Accident);   Anxiety;   Depression Intervention:   Behavioral: Helping Ease Anxiety and Depression following Stroke Sponsor:   Glasgow Caledonian University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
MONDAY, Sept. 28, 2020 -- Having two or more moderate or severe menopausal symptoms (MS) is associated with an increased risk for stroke and cardiovascular disease (CVD), according to a study presented at the annual meeting of the North American...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
(University of Leeds) Thousands of excess deaths from cardiovascular disease during the COVID-19 pandemic A major new study has identified 2085 excess deaths in England and Wales due to heart disease and stroke during the peak of the COVID-19 pandemic. On average, that is 17 deaths each day over four months that probably could have been prevented.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
Source: Risk Management and Healthcare Policy - Category: Health Management Tags: Risk Management and Healthcare Policy Source Type: research
Malignant hyperthermia (MH) and Exertional Heat Stroke (EHS) present hypermetabolic states leading to rhabdomyolysis and muscle rigidity with progressive hyperthermia; MH is triggered by volatile inhaled anesthetics, while EHS is triggered by exercise in hot/humid environment. Given the similarity of clinical features and the fact that a portion of EHS cases were diagnosed as MH susceptible by the in vitro contracture test, MH and EHS are believed to share common etiology. Mutations in RYR1 and CACNA1S have been found to be associated with MH; however the genetic cause remains to be identified in approximately 30% of MH cases.
Source: Neuromuscular Disorders - Category: Neurology Authors: Source Type: research
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