Decoding Skin Involvement in Chronic Graft-vs-Host Disease

The role of dermatologists in the care of patients with graft-vs-host disease (GVHD) following allogeneic hematopoietic stem cell transplantation varies greatly. In the acute inpatient setting, we are typically called on to perform a “diagnostic” skin biopsy of a nonspecific exanthem, but systemic management may be deferred to the primary transplant team. In the chronic setting, the skin features of GVHD are highly polymorphic and include papulosquamous eruptions, alopecia, dyspigmentation, pruritus, edema, sclerosis, fascii tis, bullae, or ulceration. Given these protean skin manifestations, ideally dermatologists should play an active role in the diagnosis and management of chronic GVHD as part of a multidisciplinary care team.
Source: JAMA Dermatology - Category: Dermatology Source Type: research

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Publication date: Available online 14 June 2019Source: Stem Cell ResearchAuthor(s): Nutnicha Tantarungsee, Zaukir Bostan Ali, Rungtip Soi-ampornkul, Chuda Rujitharanawong, Chanika Subchookul, Alisa Ritthaphai, Bootsakorn Boonkaew, Methichit Wattanapanitch, Kanchalit Thanomkitti, Daranporn Triwongwaranat, Chinnavuth Vatanashevanopakorn, Rattapon ThuangtongAbstractAn induced pluripotent stem cell (iPSC) line, MUSIi010-A, was established by Sendai virus (SeV) transduction of scalp fibroblasts from a 59-year-old male with androgenetic alopecia (AGA). Pluripotency of the iPSC line was verified by immunofluorescence staining of ...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
This study documents the prevalence and severity of AML treatment-related side effects. Methods: A national cross-sectional survey designed with the Leukemia &Lymphoma Society assessed patients' experiences with short-term (nausea/vomiting, diarrhea, hair loss, mouth sores, infection, rash) and long-term (organ dysfunction, chemobrain, fatigue, neuropathy) treatment side effects. Patient and caregiver participants rated side effect severity (none-severe). Results: Survey participants (N = 1182) were mostly female (65%), AML patients (76%), and had undergone chemotherapy (94%). Eighty-seven percent of part...
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
This study was to investigate the role and mechanism of YH0618 in ameliorating DOX-induced toxicity by in vitro and in vivo experiments. YH0618 selectively attenuated DOX-induced growth inhibition and apoptosis in human normal liver L02 cells and kidney HEK-293 cells, and simultaneously potentiated the anti-cancer effect of DOX in breast cancer MCF-7 and MDA-MB-231 cells by apoptosis pathways. Western blotting results revealed that YH0618 attenuated DOX-induced apoptosis in normal liver and kidney cells through FOXO4-mediated mitochondria-dependent mechanism. Animal experiments demonstrated that, YH0618 did not interfere i...
Source: Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Paper Source Type: research
Hair follicles (HFs) are sensitive to xenobiotic damage, which can ultimately lead to hair loss such as in chemotherapy-induced alopecia (CIA) [1]. Members of the ATP-binding cassette (ABC) transporter family fulfil a crucial role in xenobiotic, where they actively extrude drugs thereby reducing intracellular drug accumulation and limiting cellular toxicity [2]. Recently, we demonstrated that human scalp hair follicles (HFs) express an array of ABC transporter proteins, many of which localise to the anagen hair matrix (HM) and the bulge [3].
Source: Journal of Dermatological Science - Category: Dermatology Authors: Source Type: research
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Source Type: research
Authors: McCoy J, Goren A, Naccarato T, Kovacevic M, Situm M, Skudar VL, Lotti T Abstract Pattern hair loss (i.e., androgenetic alopecia) is a common condition afflicting approximately fifty percent of men and women by the age of fifty. Currently, topical minoxidil is the only US FDA approved drug for the treatment of pattern hair loss in men and women. PMID: 31184104 [PubMed - as supplied by publisher]
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
Facial plast Surg 2019; 35: 256-259 DOI: 10.1055/s-0039-1688842Medical tattooing has been used in various circumstances. In this review, the authors focus on the utilization of medical tattooing in the head and neck region as a minimally invasive alternative to corrective surgeries. It is mostly used to camouflage noticeable surgical scars on scalp, face, and perioral areas. Its use has also been described in cases of concealing depigmentation or hypopigmentation, hair loss, postirradiation telangiectasia, and congenital vascular malformation. These procedures are well-tolerated and safe. Its effects are long-lasting and s...
Source: Facial Plastic Surgery - Category: Cosmetic Surgery Authors: Tags: Original Article Source Type: research
ConclusionWe suggest that a polarized-light handheld dermatoscope is useful for revealing several typical trichoscopic features of primary cicatricial alopecias that guide clinical diagnosis. As a novel observation, our data indicate that absence of vellus hairs is not an identifying feature for frontal fibrosing alopecia.
Source: Dermatology and Therapy - Category: Dermatology Source Type: research
Background: Thyroid cancer has become the most common cancer in Korea. Generally, thyroid cancer patients have a good prognosis; however, 15%–20% of patients experience recurrence or distant metastasis or are refractory to standard treatment. We assessed the safety of sorafenib and lenvatinib in patients with advanced or metastatic radioactive iodine-refractory differentiated thyroid cancers (DTC) consecutively treated at a tertiary center in South Korea. Methods: We retrospectively reviewed the charts of all consecutive patients with DTC treated during ≥6 months with lenvatinib (February 2016–April 2018) a...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Ralph Michel Trueb, Maria Fernanda Reis Gavazzoni DiasInternational Journal of Trichology 2019 11(3):97-100 Roman Catholic tradition has made Saints the protectors of various aspects of life. Christian hagiography deals with the account of the Saints' lives and passion, and Christian iconography with the Saints' depiction in religious art. Catholic churches are full of images of Saints. Appreciation of religious art is deepened by knowledge of what is depicted. Saints are only sometimes labeled with their names. The clues to their identity are rather given in their appearance or in what they are holding. St. Rita ...
Source: International Journal of Trichology - Category: Dermatology Authors: Source Type: research
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