Cultured epidermal autografts from clinically revertant skin as a potential wound treatment for recessive dystrophic epidermolysis bullosa

Inherited skin disorders have been recently reported to have sporadic normal-looking areas, where a portion of the keratinocytes have recovered from causative gene mutations (revertant mosaicism, or “RM”). We observed a case of recessive dystrophic epidermolysis bullosa (RDEB) treated with cultured epidermal autografts (CEAs), whose CEA-grafted site remained epithelized for 16 years. We proved that the CEA product and the grafted area included cells with RM. Based on these findings, we cond ucted an investigator-initiated clinical trial of CEAs from clinically revertant skin for RDEB.

Source: Journal of Investigative Dermatology - May 1, 2019 Category: Dermatology Authors: Wakana Matsumura, Yasuyuki Fujita, Satoru Shinkuma, Shotaro Suzuki, Saki Yokoshiki, Hideki Goto, Hiroshi Hayashi, Kota Ono, Masukazu Inoie, Shota Takashima, Chihiro Nakayama, Toshifumi Nomura, Hideki Nakamura, Riichiro Abe, Norihiro Sato, Hiroshi Shimizu Tags: Original Article Source Type: research