α2δ-1–Bound N -Methyl- d -aspartate Receptors Mediate Morphine-induced Hyperalgesia and Analgesic Tolerance by Potentiating Glutamatergic Input in Rodents

Conclusionsα2δ-1–BoundN-methyl-d-aspartate receptors contribute to opioid-induced hyperalgesia and tolerance by augmenting presynapticN-methyl-d-aspartate receptor expression and activity at the spinal cord level.
Source: Anesthesiology - Category: Anesthesiology Source Type: research