Circulatory Metastin/Kisspeptin-1 (META KISS-1 Study) in Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis with Diagnostic Test Accuracy

Publication date: Available online 2 May 2019Source: Reproductive BioMedicine OnlineAuthor(s): Varikasuvu Seshadri Reddy, V. Satya Prasad, VC Vamshika, MV Satyanarayana, Panga Jaipal ReddyABSTRACTA close association of Kisspeptin-1 (KISS-1) with reproductive physiology has been reported in the literature, but the results on circulatory KISS-1 are ambiguous in patients with polycystic ovary syndrome (PCOS). We aimed to perform a systematic review and conduct a meta-analysis to evaluate the association of KISS-1 with PCOS and to test its diagnostic test accuracy (DTA) through DTA meta-analysis. Relevant studies were identified by searching PubMed and other databases in addition to manual searching of cross-references. Using random-effects model, the standardized mean differences (SMDs), pooled correlation coefficients and summary of diagnostic test accuracies were obtained. The meta-regression and sub-group analyses were performed to explore heterogeneity. The presence of publication bias was tested using funnel plot analysis. This meta-analysis finally included 12 studies. When compared with controls, the PCOS patients showed a significantly increased circulatory KISS-1 levels (SMD= 0.47, p = 0.002). Meta-analysis of correlations showed positive associations of KISS-1 with anti-mullerian hormone (AMH), luteinizing hormone (LH), free androgen index (FAI), testosterone and dehydroepiandrosterone (DHEAS) variables. The pooled diagnostic odds ratio and area under curve were 13...
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research