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Background: Falls are associated with poor prognosis in patients with Parkinson's disease (PD). Although several factors related to falls were reported in patients with PD, objective predictors of falls are not identified. We aimed to determine whet...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news

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Authors: Sawczak CM, Barnett AJ, Cohn M Abstract Hallucinations are common in Parkinson's disease (PD). Based on functional brain MRI data, hallucinations are proposed to result from alterations in the dorsal attention network (DAN), ventral attention network (VAN), and default mode network. Using structural MRI data from Parkinson's Progression Markers Initiative (PPMI), we examined cortical thickness in these networks in PD patients with (n=30) and without (n=30) minor hallucinations who were matched on multiple clinical characteristics (e.g., age, sex, education, cognitive diagnosis, MoCA score, medication, dise...
Source: Parkinsons Disease - Category: Neurology Tags: Parkinsons Dis Source Type: research
Authors: Kaya D Abstract Optimization is the process of achieving the best solution for a problem. LabVIEW based on an SVM model is proposed in this paper to get the best SVM parameters using the hybrid CS and PSO method. PCA is used as a preprocessor of SVM for reducing the dimension of data and extracting features of training samples. Also, SVM parameters are optimized for Parkinson's disease data by combining CS and PSO. The designed system is used to determine the best SVM parameters, and it is compared to PSO and CS optimization methods and found that the used CS-PSO hybrid optimization method is better. The h...
Source: Parkinsons Disease - Category: Neurology Tags: Parkinsons Dis Source Type: research
MicroRNAs: Game Changers in the Regulation of α-Synuclein in Parkinson's Disease. Parkinsons Dis. 2019;2019:1743183 Authors: Zhao L, Wang Z Abstract Parkinson's disease (PD) is the second most common neurodegenerative disorder. Its neuropathological hallmarks include neuronal loss in the substantia nigra pars compacta (SNpc) and the presence of Lewy bodies containing aggregates of α-synuclein (α-syn). An imbalance between the rates of α-syn synthesis, aggregation, and clearance can result in abnormal α-syn levels and contribute to the pathogenesis of PD. MicroRNAs (miRNAs)...
Source: Parkinsons Disease - Category: Neurology Tags: Parkinsons Dis Source Type: research
Authors: Valenti AP, Chita-Tegmark M, Tickle-Degnen L, Bock AW, Scheutz MJ Abstract Individuals with Parkinson's disease (PD) often exhibit facial masking (hypomimia), which causes reduced facial expressiveness. This can make it dif´Čücult for those who interact with the person to correctly read their emotional state and can lead to problematic social and therapeutic interactions. In this article, we develop a probabilistic model for an assistive device, which can automatically infer the emotional state of a person with PD using the topics that arise during the course of a conversation. We envision that the model c...
Source: Assistive Technology - Category: Rehabilitation Tags: Assist Technol Source Type: research
Publication date: Available online 14 June 2019Source: NeuroscienceAuthor(s): Poonam Thakur, Wei Hua Chiu, Jochen Roeper, Joshua A. GoldbergAbstractSince the landmark discovery that point mutations in the α-synuclein gene (SNCA) cause familial Parkinson's disease (PD) more than two decades ago, extensive research has been conducted to unravel the molecular and cellular mechanisms by which α-synuclein drives PD pathogenesis resulting in selective neurodegeneration of vulnerable neuronal populations. Current interest focusses on the identification of relevant toxic α-synuclein conformers and their interacti...
Source: Neuroscience - Category: Neuroscience Source Type: research
DiscussionIn our sample, DBS-SN did not result in global cognitive impairment 5 years after surgery. Verbal function was found to be significantly impaired one year after the procedure. Impaired learning and visuospatial function may be attributed to degeneration associated with PD.ResumenObjetivoEl objetivo es evaluar los efectos de la estimulación cerebral profunda del núcleo subtalámico bilateral (STN-DBS) sobre el estado cognitivo de los pacientes con enfermedad de Parkinson 5 años después de la cirugía.Materiales y métodosEn este estudio prospectivo se incluyeron 50 pac...
Source: Neurologia - Category: Neurology Source Type: research
Publication date: Available online 14 June 2019Source: Brain StimulationAuthor(s): Anca Velisar, Helen Bronte-Stewart
Source: Brain Stimulation - Category: Neurology Source Type: research
The new cost estimates, which include detailed caregiving costs, are double what had previously been reported.Medscape Medical News
Source: Medscape Neurology and Neurosurgery Headlines - Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news
PAUL SINHA, star of The Chase, has revealed he has been diagnosed with Parkinson ’s disease at the age of 49. What are the signs and symptoms of the condition?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Conclusion: Our large-scale cohort enabled us to find an age-differential standardized death risk among PD patients, with the largest increased risk at ages 60 –69 years. Comorbidities and other contributory factors warrant further investigation.Neuroepidemiology
Source: Neuroepidemiology - Category: Epidemiology Source Type: research
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