FDA Adds Boxed Warning to Insomnia Drugs

FDA Adds Boxed Warning to Insomnia Drugs
Source: eMedicineHealth.com - Category: General Medicine Source Type: news

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AbstractPurpose of reviewThe goal of the current review is to provide an update on the management of agitation in persons with dementia with a focus on pharmacological management of persons with Alzheimer ’s disease.Recent findingsAs consistently effective and safe pharmacologic interventions are still lacking, identifying and addressing medical and environmental precipitants remain a priority. Acetylcholinesterase inhibitors and memantine should be initiated to enhance cognition, and if present, management of insomnia or sundowning with trazodone is indicated. If agitation persists, treatment with citalopram can be ...
Source: Current Treatment Options in Neurology - Category: Neurology Source Type: research
AbstractFlunitrazepam (FNZ) is a potent hypnotic, sedative and amnestic drug used to treat severe insomnia. In our recent study, flunitrazepam (FNZ) metabolic profiles were investigated carefully. Six authentic human urine samples were purified using solid phase extraction (SPE) without enzymatic hydrolysis and urine extracts were then analyzed by liquid chromatography ‐Q Extractive‐HF Hybrid Quadrupole‐Orbitrap‐mass spectrometry (LC‐QE‐HF‐MS), using the full scan positive ion mode and targeted MS/MS (ddms2) technique to make accurate mass measurements. There were 25 metabolites, including 13 phase I and 12 p...
Source: Journal of Mass Spectrometry - Category: Chemistry Authors: Tags: RESEARCH ARTICLE Source Type: research
ConclusionsOur results suggest a causal role of insomnia in autism spectrum disorder and bipolar disorder. Future disease models should include insomnia as a factor for these two disorders to develop effective interventions. More detailed mechanism studies may also be inspired by this causal inference.
Source: European Psychiatry - Category: Psychiatry Source Type: research
By Christian Jarrett There is increasing recognition that while our personality traits are stable enough to shape our lives profoundly, they are also partly malleable, so that our choices and experiences can feedback and influence the kind of people we become. A new study in the Journal of Research in Personality shines a light on a highly consequential behaviour that captures this dynamic – smoking cigarettes. The results add “… to existing knowledge on the implications of smoking by showing that this behaviour is also likely to alter individuals’ characteristic ways of thinking, feeling, and beha...
Source: BPS RESEARCH DIGEST - Category: Psychiatry & Psychology Authors: Tags: Health Personality Source Type: blogs
Abstract BACKGROUND: The mechanism of Mongolian warm acupuncture (MWA) for the treatment of insomnia has not been previously reported. OBJECTIVE: To investigate the effect of MWA on gene expression profile in the p-chlorophenylalanine (PCPA)-induced rat model of insomnia. METHODS: A rat model of insomnia was established and the animals were divided into five groups: control, PCPA (untreated), PCPA+estazolam, PCPA+MA (manual acupuncture), and PCPA+MWA. The rats were euthanased at 7 days after treatment, and hypothalamic tissue was harvested to extract total RNA for the analysis of gene expression p...
Source: Acupuncture in Medicine : journal of the British Medical Acupuncture Society - Category: Complementary Medicine Authors: Tags: Acupunct Med Source Type: research
Constancy is something we perpetually search out in medicine. Patients seek medical care when there is a break from the feeling of constancy. Fatigue, insomnia, change in bowel habits, and heart palpitations are some of the most common complaints during a primary care visit. As providers, we inquire about “balanced” diets and “regular” exercise, and we seek out aberrant habits, such as cigarette and drug use and excess alcohol consumption. During the physical examination, we want to know if the “pupils are equal,” bowel sounds are “normoactive,” and whether the heart sounds a...
Source: Medical Clinics of North America - Category: Primary Care Authors: Tags: Foreword Source Type: research
More women than men have trouble sleeping, and people of both sexes with insomnia have a lower perception of quality of life, according to a study done in Sao Paulo, Brazil.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Medscape Today News Source Type: news
Authors: Yang J, Gao J Abstract Introduction: Narcolepsy is a chronic disabling condition, excessive daytime somnolence is the main symptoms of it. There is currently no cure for narcolepsy, and hence there is a great need for new treatment options. Solriamfetol is a new selective dopamine and norepinephrine reuptake inhibitor with robust wake-promoting effects. The purpose of this paper is to review solriamfetol. Areas covered: The chemical property, mechanism of action, pharmacokinetics, clinical efficacy, and safety of solriamfetol are introduced in this paper. Expert opinion: Solriamfetol can bind to dopamine a...
Source: Expert Review of Clinical Pharmacology - Category: Drugs & Pharmacology Tags: Expert Rev Clin Pharmacol Source Type: research
PURPOSE/OBJECTIVE: To determine the rate of insomnia among active-duty soldiers with and without a history of traumatic brain injury (TBI). Research Method and Design: Data were extracted from the All Army Study (AAS), a cross-sectional, self-report survey...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Distraction, Fatigue, Chronobiology, Vigilance, Workload Source Type: news
-- Waking up in the middle of the night is a surefire way to disrupt the next day's activities. Often, waking in the night is triggered by a type of insomnia, says Cleveland Clinic. Underlying health problems, such as chronic pain or acid reflux,...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
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