Age-related macular degeneration - 2012 Lancet review

From the The Lancet: Age-related macular degeneration is a major cause of blindness worldwide. With ageing populations in many countries, more than 20% might have the disorder. Advanced age-related macular degeneration is associated with progressive visual impairment. It includes two subtypes: - neovascular age-related macular degeneration (wet) - geographic atrophy (late dry) macular degeneration What are the risk factors for macular degeneration? Major risk factors include: - cigarette smoking - nutritional factors - cardiovascular diseases - genetic markers, including genes regulating complement, lipid, angiogenic, and extracellular matrix pathways How to diagnose macular degeneration? Accurate diagnosis combines clinical examination and investigations including: - retinal photography - angiography - optical coherence tomography What is the treatment for macular degeneration? Dietary anti-oxidant supplementation slows progression of the disease. Treatment for neovascular age-related (wet) macular degeneration includes intraocular injections of anti-VEGF agents. The two commonly used anti-VEGF therapies, ranibizumab and bevacizumab, have similar efficacy. Future treatments include inhibition of other angiogenic factors, and regenerative and topical therapies. References: Age-related macular degeneration. The Lancet, Volume 379, Issue 9827, Pages 1728 - 1738, 5 May 2012. Image source: Wikimedia Commons. Posted at Clinical Cases and Images. Stay upda...
Source: Clinical Cases and Images - Blog - Category: Professors and Educators Tags: Lancet Review Ophthalmology Source Type: blogs

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AbstractSince introducing optical coherence tomography (OCT) technology for 2D eye imaging, it has become one of the most important and widely used imaging modalities for the noninvasive assessment of retinal eye diseases. Age-related macular degeneration (AMD) and diabetic macular edema eye disease are the leading causes of blindness being diagnosed using OCT. Recently, by developing machine learning and deep learning techniques, the classification of eye retina diseases using OCT images has become quite a challenge. In this paper, a novel automated convolutional neural network (CNN) architecture for a multiclass classifi...
Source: Medical and Biological Engineering and Computing - Category: Biomedical Engineering Source Type: research
Researchers from Bonn University in Germany said ageing populations meant 15 per cent more people across Europe would suffer from age-related macular degeneration in 30 years' time.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
CONCLUSIONS: Approximately 67 million people in the EU are currently affected by any AMD and, due to population ageing, this number is expected to increase by 15% until 2050. Monitoring and treatment of people with advanced disease stages will require additional healthcare resources and thorough healthcare planning in the years and decades to come. PMID: 31712255 [PubMed - as supplied by publisher]
Source: The British Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Br J Ophthalmol Source Type: research
This article is intended to give an overview of possible applications. PMID: 31671463 [PubMed - as supplied by publisher]
Source: Klinische Monatsblatter fur Augenheilkunde - Category: Opthalmology Tags: Klin Monbl Augenheilkd Source Type: research
Scientists have pinpointed the glial cells and vasculature cells responsible for age-related macular degeneration.
Source: Yale Science and Health News - Category: Universities & Medical Training Source Type: news
In this study, AT1-AAs were detected in the sera of patients with peripheral arterial disease (PAD) and the positive rate was 44.44% vs. 17.46% in non-PAD volunteers. In addition, analysis showed that AT1-AAs level was positively correlated with PAD. To reveal the causal relationship between AT1-AAs and vascular aging, an AT1-AAs-positive rat model was established by active immunization. The carotid pulse wave velocity was higher, and the aortic endothelium-dependent vasodilatation was attenuated significantly in the immunized rats. Morphological staining showed thickening of the aortic wall. Histological examination showe...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Kelsey Moody of Ichor Therapeutics presented on the LysoClear development program at the Ending Age-Related Diseases conference organized by the Life Extension Advocacy Foundation earlier this year. LysoClear is an example of the commercial development of a rejuvenation therapy, taken all the way from the starting point of the discovery of microbial enzymes capable of breaking down certain forms of harmful age-related molecular waste that contribute to aging and age-related diseases. The actual research is largely done, and the task now is to focus on manufacture, regulatory approval, and entry into the clinic. Take...
Source: Fight Aging! - Category: Research Authors: Tags: Healthy Life Extension Community Source Type: blogs
NIH Director's Wednesday Afternoon Lecture Series Age-related macular degeneration (AMD) is the leading cause of blindness in the United States and in the developed world. Two NIH-supported randomized clinical trials with 10 years of follow-up in nearly 10,000 participants demonstrated that nutritional supplements with antioxidant vitamins and minerals reduces the risk of progression to late AMD. Dietary data suggest the importance of the Mediterranean diet in reducing the risk of AMD, particularly fish consumption. The analyses of the genetic interaction with nutrition challenges the idea that you can eat away your geneti...
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
Publication date: Available online 7 September 2019Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Marta Aranaz, Marta Costas-Rodríguez, Lara Lobo, Héctor González-Iglesias, Frank Vanhaecke, Rosario PereiroAbstractAge-related macular degeneration (AMD), the main cause of irreversible blindness in people over 60 years of age, is an eye disease that evolves with loss of central vision. Although AMD manifests itself in the eye, blood is continuously flowing through the macular region, such that potential alterations in this region could be reflected in the composition of whole blood or...
Source: Journal of Pharmaceutical and Biomedical Analysis - Category: Drugs & Pharmacology Source Type: research
Conclusions: Targeting monocyte recruitment via perturbation of chemokine signaling can reduce the size of experimental CNV and should be evaluated as a potential novel therapeutic modality for nvAMD. PMID: 31467935 [PubMed - in process]
Source: Journal of Immunology Research - Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
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