Safety and Efficacy of Anti-PD-1 Monoclonal Antibodies in Patients With Relapsed or Refractory Lymphoma: A Meta-Analysis of Prospective Clinic Trails

Safety and Efficacy of Anti-PD-1 Monoclonal Antibodies in Patients With Relapsed or Refractory Lymphoma: A Meta-Analysis of Prospective Clinic Trails Hui Zhou, Xiaoyan Fu, Qian Li and Ting Niu* Department of Hematology and Research Laboratory of Hematology, West China Hospital, Sichuan University, Chengdu, China Background: Immune checkpoint inhibition therapy with monoclonal antibody against programmed cell death protein 1 (PD-1), including nivolumab and pembrolizumab, has demonstrated powerful clinical efficacy in the treatment of advanced cancers. However, there is no evidence-based systematic review on the safety and efficacy of anti-PD-1 antibody in treating lymphoma. Methods: To evaluate the safety and efficacy of nivolumab/pembrolizumab, we analyzed clinical trials from PUBMED, EMBASE, and The Cochrane Library. For safety analysis, the incidence and exhibition of any grade and grade ≥3 adverse events (AEs) were evaluated. Overall response rate (ORR), 6-month progression-free survival (PFS) and 6-month overall survival (OS) were calculated for efficacy analysis. Results: Overall ten studies and 718 patients (114 non-Hodgkin lymphomas, 604 Hodgkin lymphomas) were enrolled, including 4 phase I studies and 6 phase II studies. The pooled incidences of any grade and grade ≥3 adverse events (AEs) were 74 and 24%, respectively. Drug-related deaths occurred in two patients. The most common any grade AEs were fatigue (14.91%), rash (14.8%), hypothyroidism (13.77%)...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research

Related Links:

Publication date: Available online 1 June 2020Source: Stem Cell ResearchAuthor(s): Insa Buers, Lara Schöning, Niki Tomas Loges, Yvonne Nitschke, Inga Höben, Albrecht Röpke, Laura Crisponi, Heymut Omran, Frank Rutsch
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Publication date: Available online 1 June 2020Source: Stem Cell ResearchAuthor(s): Dawid P. Grzela, Beata Marciniak, Lukasz Pulaski
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Publication date: Available online 1 June 2020Source: Stem Cell ResearchAuthor(s): Alessia Arbini, James Gilmore, Mary D. King, Kathleen M. Gorman, Janusz Krawczyk, Veronica McInerney, Timothy O'Brien, Sanbing Shen, Nicholas M. Allen
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Publication date: Available online 31 May 2020Source: Stem Cell ResearchAuthor(s): Junqing Chen, Xiaoyu Yang, Bifei Fu, Pinmou Zhu, Yunfei Zhu, Xuejiang Guo, Jiahao Sha, Yan Yuan
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Publication date: Available online 31 May 2020Source: Stem Cell ResearchAuthor(s): Kenji Tsuji, Shinji Kitamura, Yizhen Sang, Kazuhiko Fukushima, Jun Wada
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Genetic and lifestyle factors influence weight changes secondary to antidepressants. However, the association between antidepressants and weight changes is seldom studied in Middle Eastern populations who have a unique genetic, lifestyle and dietary profile. This is a chart-based retrospective longitudinal study that describes the 6-month evolution of weight in outpatient Lebanese adults initiated on serotonin reuptake inhibitor (SRI) antidepressant monotherapy, with the exclusion of confounders with metabolic implications. A linear mixed model was used to estimate the association of weight with time. Demographic factors w...
Source: International Clinical Psychopharmacology - Category: Psychiatry Tags: Original Articles Source Type: research
A high n-3, low n-6 fatty acid diet improved mood stability and reduced pain and irritability in patients with bipolar disorder.Medscape Medical News
Source: Medscape Psychiatry Headlines - Category: Psychiatry Tags: Psychiatry News Source Type: news
CONCLUSIONS: The Geographic Information System (GIS) associated with spatio-temporal scan statistics can provide timely support for surveillance and assist in decision-making.
Source: Revista da Sociedade Brasileira de Medicina Tropical - Category: Tropical Medicine Source Type: research
Abstract The novel coronavirus pneumonia (NCP) outbreak occurred in Wuhan, China at the end of 2019. Here, we report the clinical characteristics and therapeutic procedure for a case of severe NCP. The patient was started on glucocorticoids and non-invasive ventilator treatment. After treatment, the patient ’ s symptoms improved, and the status was confirmed as NCP negative. Our results may provide clues for the treatment of NCP.
Source: Revista da Sociedade Brasileira de Medicina Tropical - Category: Tropical Medicine Source Type: research
Publication date: Available online 31 May 2020Source: International Journal of Gastronomy and Food ScienceAuthor(s): Nadia Palmieri, Mariarosaria Simeone, Carlo Russo, Maria Angela Perito
Source: International Journal of Gastronomy and Food Science - Category: Food Science Source Type: research
More News: Academia | Acetaminophen | Alopecia | Arthritis | Autoimmune Disease | Belgium Health | Cancer | Cancer & Oncology | Cancer Vaccines | Carcinoma | Chemotherapy | China Health | Clinical Trials | Corticosteroid Therapy | Cough | Databases & Libraries | Dermatitis | Dermatology | Diets | Diphenoxylate | Docetaxel | Drugs & Pharmacology | Gastroenterology | Genetics | Hematology | Hodgkin's Disease | Hormones | Hypothyroidism | Immunotherapy | Infectious Diseases | Italy Health | Japan Health | Kidney Cancer | Laboratory Medicine | Leukemia | Lortab | Lung Cancer | Lung Transplant | Lymphoma | Melanoma | Men | Myeloma | Non-Small Cell Lung Cancer | Nutrition | Oral Cancer | Outbreaks | Ovarian Cancer | Ovaries | Pemphigoid | Pharmaceuticals | Pneomococcal Vaccine | Renal Cell Carcinoma | Reproduction Medicine | Respiratory Medicine | Rheumatology | Skin Cancer | Spain Health | Squamous Cell Carcinoma | Statistics | Stem Cell Therapy | Stem Cells | Study | Taxotere | Texas University | Thyroid | Thyroid Cancer | Toxicology | Transplants | USA Health | Vaccines | Vasculitis | Vitiligo | Yervoy