Safety and Efficacy of Anti-PD-1 Monoclonal Antibodies in Patients With Relapsed or Refractory Lymphoma: A Meta-Analysis of Prospective Clinic Trails
Safety and Efficacy of Anti-PD-1 Monoclonal Antibodies in Patients With Relapsed or Refractory Lymphoma: A Meta-Analysis of Prospective Clinic Trails Hui Zhou, Xiaoyan Fu, Qian Li and Ting Niu* Department of Hematology and Research Laboratory of Hematology, West China Hospital, Sichuan University, Chengdu, China Background: Immune checkpoint inhibition therapy with monoclonal antibody against programmed cell death protein 1 (PD-1), including nivolumab and pembrolizumab, has demonstrated powerful clinical efficacy in the treatment of advanced cancers. However, there is no evidence-based systematic review on the safety and efficacy of anti-PD-1 antibody in treating lymphoma. Methods: To evaluate the safety and efficacy of nivolumab/pembrolizumab, we analyzed clinical trials from PUBMED, EMBASE, and The Cochrane Library. For safety analysis, the incidence and exhibition of any grade and grade ≥3 adverse events (AEs) were evaluated. Overall response rate (ORR), 6-month progression-free survival (PFS) and 6-month overall survival (OS) were calculated for efficacy analysis. Results: Overall ten studies and 718 patients (114 non-Hodgkin lymphomas, 604 Hodgkin lymphomas) were enrolled, including 4 phase I studies and 6 phase II studies. The pooled incidences of any grade and grade ≥3 adverse events (AEs) were 74 and 24%, respectively. Drug-related deaths occurred in two patients. The most common any grade AEs were fatigue (14.91%), rash (14.8%), hypothyroidism (13.77%)...
Publication date: Available online 1 June 2020Source: Stem Cell ResearchAuthor(s): Insa Buers, Lara Schöning, Niki Tomas Loges, Yvonne Nitschke, Inga Höben, Albrecht Röpke, Laura Crisponi, Heymut Omran, Frank Rutsch
Publication date: Available online 1 June 2020Source: Stem Cell ResearchAuthor(s): Dawid P. Grzela, Beata Marciniak, Lukasz Pulaski
Publication date: Available online 1 June 2020Source: Stem Cell ResearchAuthor(s): Alessia Arbini, James Gilmore, Mary D. King, Kathleen M. Gorman, Janusz Krawczyk, Veronica McInerney, Timothy O'Brien, Sanbing Shen, Nicholas M. Allen
Publication date: Available online 31 May 2020Source: Stem Cell ResearchAuthor(s): Junqing Chen, Xiaoyu Yang, Bifei Fu, Pinmou Zhu, Yunfei Zhu, Xuejiang Guo, Jiahao Sha, Yan Yuan
Publication date: Available online 31 May 2020Source: Stem Cell ResearchAuthor(s): Kenji Tsuji, Shinji Kitamura, Yizhen Sang, Kazuhiko Fukushima, Jun Wada
Genetic and lifestyle factors influence weight changes secondary to antidepressants. However, the association between antidepressants and weight changes is seldom studied in Middle Eastern populations who have a unique genetic, lifestyle and dietary profile. This is a chart-based retrospective longitudinal study that describes the 6-month evolution of weight in outpatient Lebanese adults initiated on serotonin reuptake inhibitor (SRI) antidepressant monotherapy, with the exclusion of confounders with metabolic implications. A linear mixed model was used to estimate the association of weight with time. Demographic factors w...
A high n-3, low n-6 fatty acid diet improved mood stability and reduced pain and irritability in patients with bipolar disorder.Medscape Medical News
CONCLUSIONS: The Geographic Information System (GIS) associated with spatio-temporal scan statistics can provide timely support for surveillance and assist in decision-making.
Abstract The novel coronavirus pneumonia (NCP) outbreak occurred in Wuhan, China at the end of 2019. Here, we report the clinical characteristics and therapeutic procedure for a case of severe NCP. The patient was started on glucocorticoids and non-invasive ventilator treatment. After treatment, the patient ’ s symptoms improved, and the status was confirmed as NCP negative. Our results may provide clues for the treatment of NCP.
Publication date: Available online 31 May 2020Source: International Journal of Gastronomy and Food ScienceAuthor(s): Nadia Palmieri, Mariarosaria Simeone, Carlo Russo, Maria Angela Perito
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