The two-way relationship between cancer and atherosclerosis

Publication date: Available online 1 May 2019Source: Revista Española de Cardiología (English Edition)Author(s): Sergio Raposeiras Roubín, Alberto CorderoAbstractIn the last few years, there has been growing interest in the relationship between cancer and cardiovascular disease. The increase in life expectancy in both diseases has led to their frequent coexistence in the same patient, which can lead to adverse drug reactions that increase patient risk. This is especially relevant in the case of atherosclerosis, which seems to share a common pathophysiological substrate with cancer. In this review, we analyze these common risk factors, and specifically analyze the relationship between different cancer treatments with the risk of coronary or cerebrovascular disease, as well as the current scientific evidence on the possible relationship between antiplatelet therapy and cancer risk. We also review the incidence and prognosis of cancer in patients with atherosclerosis and vice versa, based on the information reported in the most recently published studies in the field of cardio-oncology.ResumenEn los últimos años ha emergido un interés creciente sobre la relación entre el cáncer y las enfermedades cardiovasculares. El aumento de la esperanza de vida de ambas enfermedades ha condicionado su coexistencia cada vez más frecuente en un mismo paciente, con lo cual se ponen de relieve reacciones adversas farmacológica...
Source: Revista Espanola de Cardiologia - Category: Cardiology Source Type: research

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Publication date: Available online 15 July 2019Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Emad I. Wafa, Sean M. Geary, Kathleen A. Ross, Jonathan T. Goodman, Balaji Narasimhan, Aliasger K. SalemAbstractThe primary objective of this study was to enhance the antitumor efficacy of a model cancer vaccine through co-delivery of pentaerythritol lipid A (PELA), an immunological adjuvant, and a model tumor antigen, ovalbumin (OVA), separately loaded into polyanhydride particles (PA). In vitro experiments showed that encapsulation of PELA into PA (PA-PELA) significantly enhanced its stimulatory capacity on...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - Category: Nanotechnology Source Type: research
Publication date: Available online 14 July 2019Source: Biosensors and BioelectronicsAuthor(s): Maxime Lobry, Driss Lahem, Médéric Loyez, Marc Debliquy, Karima Chah, Mariel David, Christophe CaucheteurAbstractSaccharide sensors represent a broad research area in the scope of sensing devices and their involvement in the medical diagnosis field is particularly relevant for cancer detection at early stage. In that context, we present a non-enzymatic optical fiber-based sensor that makes use of plasmon-assisted tilted fiber Bragg gratings (TFBGs) functionalized for D-glucose biosensing through polydopamine (PDA)-i...
Source: Biosensors and Bioelectronics - Category: Biotechnology Source Type: research
Publication date: Available online 15 July 2019Source: Journal of Molecular StructureAuthor(s): Mousa Al-Noaimi, Firas F. Awwadi, Wamidh H. Talib, Salem Atia, Hassan H. HammudAbstractPalladium(II) complex [Pd(HL)Cl] (1) (H2L = 2-PhS(C6H4)NH-NC=(COCH3)–NHC6H5) has been synthesized by reacting K2PdCl4 with H2L. The pincer H2L ligand is coordinated to a Pd(II) in an anionic 5π electron form via k3 –SNN to produce neutral 1-trans and 1-cis isomers in the solid state. The structures of two isomers (1-trans and 1-cis) were determined by single crystal X-ray diffraction. Furthermore, complex 1 has been characte...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Soft Matter, 2019, Accepted Manuscript DOI: 10.1039/C9SM00541B, PaperAhmet Nihat Simsek, Andrea Braeutigam, Matthias D Koch, Joshua Shaevitz, Yunfei Huang, Gerhard Gompper, Benedikt Sabass Mechanical properties of the extracellular matrix are important determinants of cellular migration in diverse processes, such as immune response, wound healing, and cancer metastasis. Moreover, recent studies indicate that even... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Soft Matter latest articles - Category: Chemistry Authors: Source Type: research
BACKGROUND: The suicide risk was higher in kidney cancer patients than in the general population. The purpose of this study was to characterize the suicide rates among kidney cancer patients and to identify the potential risk factors associated with suicid...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Suicide and Self-Harm Source Type: news
Fentanyl is a potent synthetic opioid with a variety of possible applications. Transdermal fentanyl patches are regularly prescribed for patients with severe chronic or cancer-related pain. The potential for abuse is well-known and cases associated with il...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
Shareholders have approved a plan making Flex Pharma, the neurobiology-focused biotech started five years ago by a Nobel Prize winner and one of the founders of Alnylam Pharmaceuticals Inc., into a shell company for a privately held Houston cancer drug developer.   Flex Pharma (Nasdaq: FLKS) was co-founded in 2014 by Nobel Prize Winner Rod MacKinnon and serial entrepreneur Christoph Westphal. The company began looking for a merger partner after its “tolerability concerns” arose during a mid-stage…
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news
How does ctDNA NGS compare with tissue NGS for detecting oncogenic drivers in patients with advanced lung cancers?Journal of the National Cancer Institute
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news
Cancer cells depend on lengthening their telomeres, usually via telomerase activity. Telomeres are the caps of repeated DNA sequences at the ends of chromosomes. A little length is lost with each cell division, and when short a cell either self-destructs or becomes senescent and ceases replication. Cancer cells can only replicate continually if telomeres are extended continually. Thus some research groups are looking into sabotage of telomerase or the alternative lengthening of telomeres (ALT) processes as the basis for a truly universal cancer therapy. Others, as here, are investigating ways to interfere in mechanisms tha...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
A serious incident has been declared at a trust after a backlog in scans delayed five patients’ cancer diagnosis.
Source: HSJ - Category: UK Health Source Type: news
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