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Abstract Humoral immunological defects are frequent and important causes of hypogammaglobulinemia, leading to recurrent infections, autoimmunity, allergies, and neoplasias. Usually, its onset occurs in childhood or during the second and third decades of life; however, the diagnosis is made, on average, 6 to 7 years afterwards. As a consequence, antibody defects can lead to sequelae. Here we describe the clinical-laboratory characteristics, treatment, and prognoses of patients with hypogammaglobulinemia. An observational, cross-sectional, and retrospective study of patients attending the recently established outpat...
People at high risk for serious flu complications are those with conditions such as asthma, chronic lung disease, diabetes, heart disease, morbid obesity, or adults aged 65 years or older.FDA Approvals
Authors: Lombardi C, Cottini M, Passalacqua G PMID: 30039694 [PubMed - indexed for MEDLINE]
This study aimed to extend previous research regarding the risk of psoriasis in children with asthma to an entire population subdivided by age.MethodsThe 2002 ‐2013 Korean Health Insurance Review and Assessment Service–National Sample Cohort (HIRA‐NSC) was used. The 167,693 participants with asthma were matched with 167,693 control participants for age, sex, income, region of residence, hypertension history, diabetes history, and dyslipidemia histor y. In both the asthma and control groups, the occurrences of asthma were investigated. The crude and adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) f...
This article summarizes the five main principles of personal data protection to be respected during the development of the app: purpose, proportionality and relevance, limited retention period, security and confidentiality, as well as the rights of the people who are involved in the management of the personal data (including withdrawal and modification). PMID: 31611024 [PubMed - as supplied by publisher]
By Mahboobeh Mahdavinia Alanna and Anthony are not yet ten years old, but they have been to the emergency room more times than most adults. Every few months since they were babies, their parents have raced them to the hospital for asthma attacks, superinfections of their severe eczema, or food allergy reactions. They each have […]
Conclusions:The absence of demographic or clinical predictors of OSA supports using general indications for PSG in children with ASD.Citation:Tomkies A, Johnson RF, Shah G, Caraballo M, Evans P, Mitchell RB. Obstructive sleep apnea in children with autism.J Clin Sleep Med. 2019;15(10):1469–1476.
For this ‘From the Pages of Allergy Watch’ reviews from several recent issues were selected which review articles about Allergic Skin Diseases, the focus of this issue of the Annals. The first article describes a unique minimally invasive method of skin tape stripping to identify infants with atopic derm atitis who are at increased risk for food allergy. The next study investigates the difference between IgE sensitivity and clinical reactivity to foods in children with atopic dermatitis. The last investigates the impact of UV light exposure and the development of atopic dermatitis in infancy.
Fixed airflow obstruction (FAO) is present for approximately 16% of patients with asthma, with a greater FAO incidence for patients with severe disease than for those with less severe disease.1,2 Patients with FAO have increased exacerbation frequency, decreased lung function, and greater mortality than patients without FAO.3,4 The risk of developing FAO is 2 –4-fold greater for patients with increased sputum/blood eosinophil counts than for those with lesser eosinophil counts.3–7 Elevated sputum and/or blood eosinophil counts are consensual markers of asthma with an eosinophilic phenotype.
Recent epidemiological studies suggest that non-IgE-mediated childhood food allergic disorders such as eosinophilic esophagitis (EOE), celiac disease and allergic gastroenteritis (AG), may be increasing in parallel with previously observed increases in childhood IgE-mediated food allergy (FA) and food-induced anaphylaxis (FIA)1-4. The term AG encompasses food protein induced enterocolitis syndrome (FPIES), eosinophilic enteritis and colitis, food protein induced enteropathy, food hypersensitivity enteritis and colitis, but not EOE.