Recent Advances in Therapeutic Applications of Bisbenzimidazoles.

Recent Advances in Therapeutic Applications of Bisbenzimidazoles.
Med Chem. 2019 Apr 16;:
Authors: Verma S, Ravichandiran V, Ranjan N, Flora SJS
Abstract
Nitrogen-containing heterocycles are one of the most common structural motifs in approximately 80% of the marketed drugs. Of these, benzimidazoles analogues are known to elicit wide spectrum pharmaceutical activities such as anticancer, antibacterial, antiparasitic, antiviral, antifungal as well as chemosensor effect. Based on the benzimidazole core fused heterocyclic compounds, crescent shaped bisbenzimidazoles were developed which provided an early breakthrough in the sequence-specific DNA recognition. Over the years, a number of functional variations in the bisbenzimidazole core have led to the emergence of their unique properties and established them as versatile ligands against several classes of pathogens. The present review provides an overview of diverse pharmacological activities of the bisbenzimidazole analogues in the past decade with a brief account of its development through the years.
PMID: 31038072 [PubMed - as supplied by publisher]

Source: Medicinal Chemistry - April 15, 2019 Category: Chemistry Authors: Verma S, Ravichandiran V, Ranjan N, Flora SJS Tags: Med Chem Source Type: research