Regression of renal angiomyolipomas with oral rapamycin therapy in a patient with tuberous sclerosis complex disease.

We present a case of a 32-year-old female who had been diagnosed tuberous sclerosis complex (TSC) two years ago. In view of serious hemorrhagic complication risk of the selective embolization, we commenced her on oral rapamycin therapy for regression of angiomyolipomas (AMLs). On the 1st year of rapamycin treatment, bilateral renal AMLs were regressed and bilateral selective embolization of the AML was performed after the 1st year of treatment. Rapamycin therapy may regress renal lesions in TSC disease. Therefore, it may increase surgical intervention. PMID: 31031395 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/31031395?dopt=Abstract

Source: Saudi Journal of Kidney Diseases and Transplantation - February 28, 2019 Category: Urology & Nephrology Authors: Torun D, Micozkadioglu H, Gedikoglu M, Ozelsancak R, Tekkarismaz N Tags: Saudi J Kidney Dis Transpl Source Type: research