Maternal Restricted- and Over-Feeding During Gestation Result in Distinct Lipid and Amino Acid Metabolite Profiles in the Longissimus Muscle of the Offspring

Conclusion Poor maternal nutrition during gestation can negatively affect muscle and offspring development. We demonstrate here that over- and restricted-feeding during gestation alters metabolite abundance in the offspring muscle in a diet-specific manner. Together, these data suggest that poor maternal diet during gestation causes metabolic changes in offspring skeletal muscle, which likely have long-lasting effects on the potential for muscle growth, muscle metabolism, and importantly, whole body metabolism and energy efficiency. Ethics Statement This study was carried out in accordance with the recommendations of the University of Connecticut Institutional Animal Care and Use Committee. The protocol was approved by the University of Connecticut Institutional Animal Care and Use Committee. Author Contributions DM participated in design and coordination, analyzed data, and drafted the manuscript. AJ, SP, MH, KM, KG, and SZ participated in design and coordination and critically evaluated the manuscript. SR conceived of the study, participated in design and coordination, analyzed data, and drafted the manuscript. All authors read and approved the final manuscript. Funding This work was supported by USDA National Institute of Food and Agriculture AFRI grant numbers 2013-01919 (to SZ) and 2016-67016-24863 (to SR) and the Storrs Agricultural Experiment Station. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any comme...
Source: Frontiers in Physiology - Category: Physiology Source Type: research