Genome-Wide Interaction and Pathway Association Studies for Body Mass Index

Genome-Wide Interaction and Pathway Association Studies for Body Mass Index Hongxiao Jiao1, Yong Zang2, Miaomiao Zhang2, Yuan Zhang2, Yaogang Wang3, Kai Wang4,5*, R. Arlen Price6* and Wei-Dong Li2* 1Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin, China 2Department of Genetics, College of Basic Medical Sciences, Tianjin Medical University, Tianjin, China 3College of Public Health, Tianjin Medical University, Tianjin, China 4Raymond G. Perelman Center for Cellular and Molecular Therapeutics, Children’s Hospital of Philadelphia, Philadelphia, PA, United States 5Laboratory Medicine, Department of Pathology, University of Pennsylvania, Philadelphia, PA, United States 6Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States Objective: We investigated gene interactions (epistasis) for body mass index (BMI) in a European-American adult female cohort via genome-wide interaction analyses (GWIA) and pathway association analyses. Methods: Genome-wide pairwise interaction analyses were carried out for BMI in 493 extremely obese cases (BMI> 35 kg/m2) and 537 never-overweight controls (BMI
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research

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