Atypical clinical features associated with mixed pathology in a case of non-fluent variant primary progressive aphasia.
Atypical clinical features associated with mixed pathology in a case of non-fluent variant primary progressive aphasia. Neurocase. 2019 Apr 29;:1-9 Authors: De Leon J, Mandelli ML, Nolan A, Miller ZA, Mead C, Watson C, Welch AE, Henry ML, Bourakova V, La Joie R, Bajorek LP, Grinberg L, Rabinovici G, Miller BL, Gorno-Tempini ML Abstract A 66-year-old woman presented with agrammatism and apraxia of speech, meeting criteria for non-fluent/agrammatic variant primary progressive aphasia (nfvPPA). However, three years later, she developed frontal/executive, short-term phonological memory, visuospatial, and visual memory deficits suggesting involvement of multiple brain networks. Multimodal neuroimaging showed damage of both fronto-striatal and posterior brain regions. She was found to have multiple pathological processes: corticobasal degeneration (CBD), Alzheimer's disease (AD), and TAR DNA-binding protein (TDP)-43 type A. We hypothesize that cognitive and neuroimaging findings consistent with damage to multiple brain networks, each associated with vulnerability to certain molecular disease subtypes, could indicate mixed pathology. PMID: 31033382 [PubMed - as supplied by publisher]
Conditions: Alzheimer Disease, Early Onset; Atypical Alzheimer's Disease; Logopenic Progressive Aphasia Interventions: Device: Anodal tDCS; Device: Sham; Other: Word list learning therapy Sponsor: Johns Hopkins University Not yet recruiting
AbstractThe utility of tau PET imaging in non-Alzheimer ’s disease (AD) tauopathies like behavioural frontotemporal dementia (bvFTD), which is mainly underlain by TDP-43 or tau pathology, remains debated. We aim to test the hypothesis that [18F]-AV-1451 tau PET using later than usual acquisition times, which have previously been shown in AD to allow to get closer to tracer equilibrium between the reference region and high-binding structures, and could be better suited to the lower affinity of this tracer for the straight tau filaments present in non-AD tauopathies, would allow to detect cortical tau pathology in a fr...
DISCUSSION: The BEHAV and LANG domains enable the CDR® plus NACC FTLD to capture early symptomatology of FTLD. PMID: 31477517 [PubMed - as supplied by publisher]
DiscussionThe BEHAV and LANG domains enable the CDR® plus NACC FTLD to capture early symptomatology of FTLD.
ConclusionsAlthough cortical degeneration in AD-related PPA is maximal in the left posterior perisylvian region, it extends more diffusely throughout the left hemisphere language network offering a plausible explanation for why the linguistic profile of lvPPA so often includes additional semantic and grammatic deficits.
Conditions: Alzheimer Disease; Primary Progressive Aphasia; Mild Cognitive Impairment Intervention: Device: repetitive transcranial magnetic stimulation (rTMS) Sponsor: Brigham and Women's Hospital Recruiting