Uterine Natural Killer Cells

Conclusions In both mouse and human, uNK cells are the most prominent immune cells that occupy the maternal-fetal interface. The uNK cells appear to engage and establish complex interactions with the surrounding tissue, which impact their function. As more cell subsets are identified within the heterogeneous uNK cell population, it is anticipated that their functional heterogeneity will extend beyond vascular modification, growth-promotion and memory generation. Author Contributions DS wrote the manuscript. LY provided the micrographs and WY edited the manuscript. Funding Work in the Yokoyama lab on uterine NK cells is supported by grant R01-AI140397 from the National Institutes of Health. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. References 1. Gasteiger G, Fan X, Dikiy S, Lee SY, Rudensky AY. Tissue residency of innate lymphoid cells in lymphoid and nonlymphoid organs. Science. (2015) 350:981–5. doi: 10.1126/science.aac9593 PubMed Abstract | CrossRef Full Text | Google Scholar 2. Barrow AD, Colonna M. Innate lymphoid cell sensing of tissue vitality. Curr Opin Immunol. (2018) 56:82–93. doi: 10.1016/j.coi.2018.11.004 PubMed Abstract | CrossRef Full Text | Google Scholar 3. Sojka DK, Tian Z, Yokoyama WM. Tissue-resident natural killer cells and their potential diversity. Semin Immu...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research

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