Recurrent atherosclerosis complications as a mechanism for stent failure.

Recurrent atherosclerosis complications as a mechanism for stent failure.
Hellenic J Cardiol. 2019 Apr 26;:
Authors: Andreou I, Stone PH, Ikonomidis I, Alexopoulos D, Sabaté M
Abstract
Stents are an indispensable tool in the percutaneous treatment of symptomatic coronary artery disease. Yet, stent failure due to restenosis or thrombosis may compromise their clinical benefit, carrying substantial morbidity and mortality. Despite improvements in device design and adjunctive medical treatment, stent failure still occurs during long-term follow-up, suggesting that this may be an issue that persists for many years, perhaps indefinitely. Numerous studies during the last decade have highlighted the previously underappreciated pivotal role of atherosclerosis in stent failure. We review evolving evidence on the role of atherosclerosis in stent restenosis and thrombosis, differentiating between de novo in-stent atherosclerosis development (i.e., neoatherosclerosis) and progression of pre-existing underlying atherosclerosis (i.e., paleoatherosclerosis), a distinction with potentially important clinical implications. We conclude with a concept that provides a unifying pathophysiology for these significant problems in the field of interventional cardiology based on the progression and destabilization of atherosclerosis.
PMID: 31034959 [PubMed - as supplied by publisher]

Source: Hellenic Journal of Cardiology - May 1, 2019 Category: Cardiology Tags: Hellenic J Cardiol Source Type: research