Distinct Roles of Outer Membrane Porins in Antibiotic Resistance and Membrane Integrity in Escherichia coli

Conclusion In conclusion, our systematic study shows two possible roles of porins, the transport of antibiotics and the membrane integrity regulation, which differently affect antibiotic resistance, and the distinct role of each porin. This provides an important insight to understand not only the role of each porin as a functionally important component of the outer membrane, but also its specific role in the survival of the pathogen under the action of antibiotics. Data Availability All datasets generated for this study are included in the manuscript and/or the Supplementary Files. Author Contributions C-RL contributed to the conception and design of the experiments. C-RL and UC researched and wrote the manuscript. Funding This work was supported by research grants from the NRF funded by the Ministry of Science and ICT (No. NRF-2018R1A1A1A05023049) and the Bio Medical Technology Development Program of the NRF funded by the Korean Government, MSIT (NRF-2017M3A9E4078017). Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Supplementary Material The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fmicb.2019.00953/full#supplementary-material References Bornet, C., Davin-Regli, A., Bosi, C., Pages, J. M., and Bollet, C. (2000). Imipenem resistance of Enter...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research