Single-dose brachytherapy treats low-risk prostate cancer
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CONCLUSION: The principal findings of this investigation were that low testosterone is correlated with elevated CgA levels, and these two parameters are associated with more aggressive grades and higher pathological stages of prostatic adenocarcinoma. KEY WORDS: Chromogranin A, Prostate cancer, Risk factor for prostate cancer, Testosterone. PMID: 31203267 [PubMed - as supplied by publisher]
Publication date: Available online 18 June 2019Source: Life SciencesAuthor(s): Sina Rahimi, Amaneh Mohammadi Roushandeh, Ammar Ebrahimi, Ali Akbar Samdani, Yoshikazu Kuwahara, Mehryar Habibi RoudkenarAbstractAimsLipocalin 2 (Lcn2/NGAL) belongs to lipocalin superfamily with diverse functions. The precise function of Lcn2, particularly in cancer development, remains to be elucidated yet. In an attempt to knockout of Lcn2 expression by CRISPR/Cas 9 technology in a highly aggressive and invasive prostate cancer cell line and to evaluate the combination therapy with cisplatin (CDDP), this study was conducted.Main methodsControl...
PMID: 31204661 [PubMed - in process]
Conclusion: The biopsy protocol that included six end-fire anterior cores did not detect more cancer and was associated with more complications. PMID: 31204873 [PubMed - as supplied by publisher]
Conclusions: PCa patients with MSCC have a poor prognosis. Most likely reflecting differences in tumor burden, preserved gait function following radiotherapy is associated with better prognosis. Further prospective studies are required to confirm this association. PMID: 31204549 [PubMed - as supplied by publisher]
Condition: Prostate Cancer Intervention: Drug: Leuprolide Acetate Sponsor: Laboratoires Bouchara-Recordati Not yet recruiting
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Contributors : Chaima Cherif ; Julien Vernerey ; Nadine Carbuccia ; Palma Rocchi ; Estelle DuprezSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensMenin protein is encoded by the multiple endocrine neoplasia type 1 (MEN1) gene. It remains an enigmatic protein, known as a tumor suppressor but its roles in cancer development have attracted significant attention in recent years. The goals of this study is to understand how the Menin tumor suppressor can be oncogenic in Prostate, we have profiled Menin chromatin occupancy by chromatin immunoprecipitation coupled to high-throug...