FDA Expands Indication for PCSK9 Alirocumab (Praluent) FDA Expands Indication for PCSK9 Alirocumab (Praluent)

The decision allows the cholesterol-lowering drug to be prescribed to reduce the risk for major cardiovascular events, including myocardial infarction and stroke.Medscape Medical News
Source: Medscape Neurology and Neurosurgery Headlines - Category: Neurology Tags: Cardiology News Source Type: news

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This study sought to investigate what could be learned from how these men have fared. The men were born in 1925-1928 and similar health-related data from questionnaires, physical examination, and blood samples are available for all surveys. Survival curves over various variable strata were applied to evaluate the impact of individual risk factors and combinations of risk factors on all-cause deaths. At the end of 2018, 118 (16.0%) of the men had reached 90 years of age. Smoking in 1974 was the strongest single risk factor associated with survival, with observed percentages of men reaching 90 years being 26.3, 25.7, ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
WEDNESDAY, June 19, 2019 -- Radiation treatment for cancer can damage the heart and blood vessels, increasing the risk for a stroke or heart attack. But a new study suggests cholesterol-lowering drugs can significantly reduce that risk. The...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
We reported that plasma levels of angptl2 are elevated in patients with cardiovascular diseases (CVD), were associated with endothelial dysfunction, and were predictive of major cardiac adverse events and death. Recently, we reported a strong relationship between arterial expression of p21, a cell cycle inhibitor overexpressed in senescent cells and maintaining growth arrest, and circulating levels of angptl2 in atherosclerotic patients. Senescent EC are activated and promote aggregation of leukocytes, the initiating step of atherogenesis. We therefore hypothesized that down-regulation of vascular angptl2, preferentially i...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
ConclusionsIntensification of LLT in an ASCVD population translates into a substantial number of CV events avoided. This simulation-based model could assist in assessing the potential benefits of various types of population-level LLT interventions.
Source: American Heart Journal - Category: Cardiology Source Type: research
Looking for clues about the health of your brain? You might want to pay a visit to your eye doctor. Research increasingly links common eye conditions — glaucoma, age-related macular degeneration, and diabetic retinopathy — to risk for Alzheimer’s and other forms of dementia. What’s interesting about the study results, says Dr. Albert Hofman, chair of epidemiology at the Harvard T.H. Chan School of Public Health, is that cataracts, another common age-related eye condition, had no apparent connection to dementia risk. This gives scientists an important clue about the cause of dementia and Alzheimer&rs...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Alzheimer's Disease Brain and cognitive health Eye Health Source Type: blogs
ConclusionInvasive management was underused and profoundly deferred among patients with NSTEMI in China. The risk-treatment paradox, procedure deferral and medical resources distribution imbalance may represent opportunities for improvement.
Source: American Heart Journal - Category: Cardiology Source Type: research
(CNN) — The red meat or white meat debate is a draw: Eating white meat, such as poultry, will have an identical effect on your cholesterol level as eating red beef, new research indicates. The long-held belief that eating white meat is less harmful for your heart may still hold true, because there may be other effects from eating red meat that contribute to cardiovascular disease, said the University of California, San Francisco researchers. This needs to be explored in more detail, they added. Non-meat proteins such as vegetables, dairy, and legumes, including beans, show the best cholesterol benefit, according to t...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News Cholesterol CNN Red Meat Source Type: news
Authors: Santoso A, Heriansyah T, Rochman S Abstract Lipoprotein-associated phospholipase A 2 (Lp-PLA 2 ) is an enzyme family of phospholipase A 2 produced by the inflammatory cell in atherosclerotic plaque. It is transported in the circulation, attached mainly to low-density lipoprotein-cholesterol (LDL-C). It hydrolyzes glycerophospholipids particularly fatty acids at the sn-2 position and produces numerous bioactive lipids; and leads to endothelial dysfunction, atherosclerotic plaque inflammation, and development of the necrotic core in plaques. There are two kinds of phospholipase A 2 , namely: secretory phosph...
Source: Current Cardiology Reviews - Category: Cardiology Tags: Curr Cardiol Rev Source Type: research
We describe the case of a 53-year-old Brazilian man who was referred to our center due to the diagnosis of liver cirrhosis of unknown etiology. He was asymptomatic and had normal body mass index. He had dyslipidemia, and family history of myocardial infarction and stroke. Abdominal imaging tests showed liver cirrhosis features and the presence of intrahepatic calcifications. Initial investigation of the etiology of the liver disease was not elucidated, but liver biopsy showed microgoticular steatosis and cholesterol esters deposits in Kuppfer cells. The dosage of serum lysosomal acid lipase was undetectable and we found th...
Source: Annals of Hepatology - Category: Gastroenterology Tags: Ann Hepatol Source Type: research
CONCLUSIONSConsistent statin therapy was significantly associated with better prognosis after coil embolization or surgical clipping of cerebral aneurysms. PMID: 31125972 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - Category: Neurosurgery Authors: Tags: J Neurosurg Source Type: research
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